白细胞介素1诱导牛脑微血管平滑肌细胞增殖及甘糖酯的拮抗作用  

Interleukin-1 Induced Proliferation of Bovine Cerebromicrovessel Smooth Muscle Cells and Antagonism by Propylene Glycol Mannate Sulfate in Culture

作　　者：张岫美[1] 孙晓红[2] 魏欣冰[1] 张敏[1] 盛少虎[1] 张斌[1] 

机构地区：[1]山东医科大学基础医学院药理学教研室,250012 [2]中国人民解放军464医院

出　　处：《中国生化药物杂志》1999年第2期74-76,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：山东省科委资助!9016

摘　　要：用牛脑微血管平滑肌细胞（ＢＣＭＳＭＣ）体外培养技术，研究白细胞介素１（ＩＬ－１）对ＢＣＭＳＭＣ增殖的影响。浓度为５０ｕ／ｍｌ的 ＩＬ－１与ＢＣＭＳＭＣ共同孵育７２ｈ，即可明显诱导ＢＣＭＳＭＣ增殖。甘糖酯在０．２、０．４、０．８、１．６ｍｇ／ｍｌ的浓度下可显著抑制ＩＬ－１诱导的ＢＣＭＳＭＣ增殖。提示甘糖酯对脑血管疾病的防治作用可能与抑制血管平滑肌细胞的异常增殖有关。The effects of Interleukin-l on the proliferation of bovine cercbromicrovessel smooth muscle cells (BCMSMC) in culture were investigated. IL-1 induced proliferation of cultured BCMSMC was at the concentration of 50u/ml after 72h incubation. The results showed that propylene glycol mannate sulfate (PGMS) antagonized the proliferation of BCMSMC induced by IL-1 at, the concentration of 0.2, 0.4, 0. 8, 1.6mg/ml. It was suggested that the inhibition effects of PGMS on BCMSMC proliferation might probably play an important role in the potential use for cerebrovascular diseases.

关 键 词：甘糖酯 IL-1 脑血管疾病 BCMSMC 拮抗作用 

分 类 号：R979.5[医药卫生—药品]