妊娠期高血压病伴高同型半胱氨酸血症的临床研究与护理  

Clinical Studies and Nursing on Patients with Hypertensive Disorder Complicating Pregnancy Accompanied with Hyperhomocysteinemia

作　　者：黎小珊[1] 熊莲花[1] 董睿[1] 

机构地区：[1]广东省东莞市人民医院,东莞523018

出　　处：《临床护理杂志》2010年第4期2-3,66,共3页Journal of Clinical Nursing

摘　　要：目的探讨叶酸联合甲钴胺治疗妊娠期高血压病伴高同型半胱氨酸(Hcy)血症患者的临床观察与护理。方法对95例子痫前期伴高(Hcy)血症患者随机分成A、B、C三组,A组采用叶酸治疗,B组采用甲钴胺治疗,C组采用叶酸联合甲钴胺治疗。监测治疗后患者血浆总同型半胱氨酸(tHcy)水平、血清叶酸、维生素B12水平及平均动脉压和24h尿蛋白定量。结果 C组和A组治疗后血浆tHcy水平较治疗前显著下降(P<0.05),血清叶酸水平较治疗前显著升高(P<0.01)。平均动脉压与24h尿蛋白定量较治疗前显著下降(P<0.05,P<0.01),且C组显著低于A组(P<0.05)。C组和B组血清维生素B12水平治疗后较治疗前显著升高(P<0.05)。结论 C组比A组、B组降低患者血浆tHcy水平、平均动脉压和24h尿蛋白定量疗效更显著。经过精心护理,患者临床症状消失快,提高治疗成功率,改善患者的转归,具有积极的临床意义。Objective To explore the effect of clinical observation and nursing care about patients with hypertensive disorder complicating pregnancy accompanied with hyperhomocysteinemia（Hcy）treated by single therapy or combination of folic acid and methylcobalamin.Methods ： 95 cases of hypertensive disorder complicating pregnancy accompanied with hyperhomocysteinemia were randomly divided into three groups： group A treated by folic,group B treated by methylcobalamin,group C treated by folic and methylcob.And Observethe levels of plasma tHcy,serum folic acid,vitamin B12,mean arterial blood pressure,24 hour fixed quantity of Urine protein on prior treatment and post-treatment.Results The prior treatment levels of plasma tHcy were lower than the post-treatmen（P0.05）,but the prior treatment levels of serum folic acid were higher（P0.01） in group A and group C.The prior treatment numerus of mean arterial blood pressure and 24 hour fixed quantity of Urine protein were less than post-treatmen（P0.05,P0.01） in group A and group C.And the numerus of those in group C were much less than group A（P0.05）.The post-treatment level of vitamin B12 were higher than the prior treatment（P0.05） in group C and group B.Conclusion Making the levels of plasma tHcy,mean arterial blood pressure,24 hour fixed quantity of Urine protein lower on post-treatmen than prior treatmen.Group C is the most effectively in the study.By good nursing,the patients＇ clinical symptoms could disappear more quickly,we could cure more patients and the method could be benefic for health.And it show actively clinical significance.

关 键 词：高血压 妊娠期/护理 高同型半胱氨酸血症 

分 类 号：R544.1[医药卫生—心血管疾病] R714.246[医药卫生—内科学]