超微粉碎工艺对肿痛消巴布剂中蒲黄透皮吸收的影响研究  

Study on effect of ultramicro-shatter technology on penetrating skin absorption of Pollen Typhae in Zhongtongxiao Cataplasm

作　　者：李跃辉[1] 杨瑛[1] 杨永华[1] 蔡光先[1] 易延逵[2] 

机构地区：[1]湖南省中医药研究院医药粉体工程实验室,长沙410006 [2]南方医科大学,广州510515

出　　处：《中华中医药杂志》2010年第9期1483-1485,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省科技厅重点项目(No.06SK2005)~~

摘　　要：目的:研究超微粉碎对肿痛消巴布剂中异鼠李素-3-O-新橙皮苷透皮吸收的影响。方法:利用改良Frans透皮吸收池进行体外透皮试验,HPLC法测定超微肿痛消与普通肿痛消中异鼠李素-3-O-新橙皮苷含量。结果:超微肿痛消巴布膏剂的Q-t方程为Q=3.0382t+47.082、透皮速率为3.0382(μg.cm2/h),普通肿痛消巴布膏剂的Q-t方程为Q=2.7967t+39.752、透皮速率为2.7967(μg.cm2/h)。结论:超微肿痛消巴布剂中异鼠李素-3-O-新橙皮苷累计渗透量与透皮速率均优于其普通肿痛消巴布剂,说明超微粉碎技术加快了药物成分的溶出。Objective：To study the effect of ultramicro-shatter technology on penetrating skin absorption of isorhamnetin-3-O-neohesperidin in Zhongtongxiao Cataplasm.Methods：To apply reformed Frans penetrating skin absorption cell marching extraorgan penetrating skin experiment.HPLC method was used to determine the content of isorhamnetin-3-Oneohesperidin in ultramicro-shatter Zhongtongxiao Cataplasm and in common Zhongtongxiao Cataplasm.Results：The Q-t equation of ultramicro-shatter Zhongtongxiao Cataplasm：Q=3.0382t＋47.082,penetrating skin velocity：3.0382（μg.cm2/h）;the Q-t equation of common Zhongtongxiao Cataplasm：Q=2.7967t＋39.752,penetrating skin velocity：2.7967（μg.cm2/h）;Extraction rate of dynamic extracting micro-powder,the ephedrina hydrochloridum,glycyrrhizic acid and glycyrrhizae glycoside were higher than the trdtional cut crude drug decocting.Conclusion：The accumulating osmolality and penetrating skin velocity of isorhamnetin-3-O-neohesperidin in ultramicro-shatter Zhongtongxiao Cataplasm were all better than those in common Zhongtongxiao Cataplasm,it explained that ultramicro-shatter technology accelerate the dissolution of medicine compsitions.

关 键 词：超微粉碎 肿痛消巴布剂 异鼠李素-3-O-新橙皮苷 透皮吸收 高效液相 

分 类 号：TQ461[化学工程—制药化工]