黄芪潜在功能的药效学研究  

Pharmacological effects of Astragali’potential functions

作　　者：郑曙琴[1] 梁茂新[1] 安然[1] 

机构地区：[1]辽宁中医药大学附属医院,沈阳110032

出　　处：《中华中医药杂志》2010年第9期1510-1512,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：教育部高等学校博士学科点专项科研基金(No.20070162004);辽宁省教育厅课题(No.2006T094)~~

摘　　要：目的:考察黄芪潜在的止痛、安神及止血功能。方法:分别观察黄芪水煎剂高、中、低剂量对小鼠物理致痛(热板法)和化学致痛(扭体法)反应的影响;对小鼠戊巴比妥钠阈下催眠量作用和戊巴比妥钠催眠时间的影响以及对大鼠凝血功能的影响,并和空白对照组以及中、西药阳性对照药进行比较。结果:黄芪水煎剂能提高小鼠的痛阈,减少小鼠的扭体次数,对戊巴比妥钠阈下催眠量小鼠睡眠有增强作用,延长小鼠戊巴比妥钠催眠作用时间。此外,能够缩短凝血酶原时间及部分凝血活酶时间,增加纤维蛋白原。结论:黄芪具有确切的止痛、安神以及止血功能。这与古代方剂数据库检索含黄芪方剂的病证分布的分析结论是一致的。Objective：To study potential function of relieving-pain,calming and stopping bleeding function of astragali.Methods：To observe the effect of the water decoction of high,middle and low doses astragali on physical pain（hot plate method） and chemical-induced pain（writhing method）in mice reaction;the effect on the sleep durance of mouse which was applied under valve dosage of sodium pentobarbital and impact of blood coagulation in rats.It was compared with the blank control group,as well as the positive control group.Results：Astragali decoction can increase the pain threshold in mice,reduce the number of writhing in mice,enhance the volume of the role of sleep in mice on the threshold of sodium pentobarbital hypnosis,and extend the role of sodium pentobarbital hypnosis time.At the same time can shorten the prothrombin time and partial thromboplastin time,and increase fibrinogen.Conclusion：Astragali had definite relieving-pain,calming and stopping bleeding function.This result was consistent with the analysis conclusions through ancient prescriptions database with astragali.

关 键 词：黄芪 潜在功能 止痛 安神 止血 药效学 

分 类 号：R285.5[医药卫生—中药学]