丹参水蛭胶囊对血管支架成型术后再狭窄预防作用的比较研究  

Clinical study of Danshen Shuizi Capsule in preventing restenosis after stent placement intervention

作　　者：任丁[1] 吴云虎[1] 黄建民[1] 王凯华[1] 

机构地区：[1]广西中医学院附属瑞康医院,南宁530011

出　　处：《中华中医药杂志》2010年第9期1518-1520,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广西卫生厅重点课题基金项目(No.200940)~~

摘　　要：目的:评价丹参水蛭胶囊应用于预防支架内再狭窄的效果。方法:以48例血管内支架成型术术后患者作为研究对象。术后随机分为两组,中药治疗组服用丹参水蛭胶囊;西药对照组应用抵克力得治疗。术后6个月复查脑血管造影,计算机定量测定血管病变的直径狭窄程度(QCA)。结果:治疗组(n=23)参照血管直径与对照组(n=25)比较无明显差异,支架段血管直径差异不明显(2.22±0.21)mmvs(2.18±0.25)mm。血管直径减少指数治疗组与对照组分别为(0.50±0.16)mm、(0.51±0.11)mm。治疗组再狭窄率(17.4%)及再介入率(13.1%)与对照组(20%、12%)比较,差异无统计学意义,但治疗组并发症明显低于对照组。结论:丹参水蛭胶囊干预可降低血管内支架成型治疗术后再狭窄的发生率,且有较少的并发症。Objective：To evaluate the preventive effect of Danshen Shuizi Capsule on vascular restenosis after stent implantation.Methods：48 patients with endovascular stent implantation were randomly assigned to control group（n=25） （treated with western medicines）and treatment group（n=23）（treated with Danshen Shuizi Capsule）after endovascular stenting implantation.The intraluminal diameter of stenting segment was measured by QCA at 6 months after stent implantation.Results： The diameter of reference vessel in two groups was not significantly different.The intraluminal diameter of stent segment in the treatment group was not larger than that in the control group（2.22±0.21）mm vs（2.18±0.25）mm.The index number of vessel diameter reduction in treatment group was not less than that in the control group（0.50±0.16）mm vs（0.51±0.11）mm.The rate of restenosis（18.4%）and reintervention（13.1%）in treatment group were not lower than those in the control（20%,12%）.However,the complication in treatment group was significantly lower than that in control group.Conclusion：These findings indicated that endovascular was useful for the prevention of endovascular restenosis after stent implantation with fewer complications

关 键 词：介入治疗 支架再狭窄的预防与控制 丹参水蛭胶囊 

分 类 号：R277.7[医药卫生—中医学]