支气管上皮细胞在呼吸道免疫紊乱中的作用  

Role of bronchial epithelial in dysfunction of respiratory immunity

作　　者：秦岭[1] 胡成平[1] 

机构地区：[1]中南大学湘雅医院呼吸内科,长沙410008

出　　处：《国际病理科学与临床杂志》2010年第4期304-308,共5页Journal of International Pathology and Clinical Medicine

基　　金：国家重点基础研究发展计划(973)(2009CB522104)~~

摘　　要：呼吸道免疫紊乱是气道高反应性疾病的重要发病机制,其主要反映为嗜酸性粒细胞(eosinophils,EOS)肺内浸润,通过脱颗粒作用,释放细胞毒性物质;辅助性T淋巴细胞(help T cells,Th细胞)亚群异常漂移,使Th2相对亢进,Th1相对低下。支气管上皮细胞(bronchial epithelial cells,BECs)是机体对外保护的第一道屏障。在外源性抗原物质的刺激下,它通过释放炎症信号、抗原提呈、协同刺激等功能指导EOS和Th细胞的活化、迁移以及分化,从而导致气道免疫失衡。Dysfunction of respiratory immunity is one of the most important pathogenesis in airway hyperreactivity（AHR）.In the process of AHR,eosinophils（EOS） infiltrate into lung and release cytotoxic substances by degranulation.The subsets of help T（Th） cells drift abnormally,leading Th2 subsets more active than Th1.Bronchial epithelial cells（BECs） are the main barrier to protect the body against outside invading.When stimulated by exogenous antigen,BECs modulate the activation,migration and differentiation of both EOS and Th cells through the release of inflammatory substances,angtigen presentation or costimulation,resulting in immunity imbalance in respiratory tracts.

关 键 词：支气管上皮细胞 免疫紊乱 嗜酸性粒细胞 辅助性T淋巴细胞 

分 类 号：R56[医药卫生—呼吸系统]