空腹血清C肽水平与2型糖尿病肾病相关性分析  

Correlation analysis between fasting serum connecting peptide level with Type 2 diabetic nephropathy

作　　者：刘俊峰[1] 袁慧忠 黄娟[1] 鞠萍[1] 杨浏[1] 

机构地区：[1]湖北省黄石市第二医院检验科,435002 [2]湖北省黄石市第二医院肾病内科,435002

出　　处：《国际检验医学杂志》2010年第8期822-823,826,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨2型糖尿病(DM)患者空腹血清C肽(FCP)水平与糖尿病肾病(DN)患者发病因素相关分析。方法回顾性分析本院2006年6月至2008年12月258例DM患者,其中DM组187例,DN组71例。通过分析患者FCP水平、肾小球滤过率(GFR)、血脂、肾功能、糖化血红蛋白(HbA1c)、尿微量清蛋白(mA1b)等指标,进行相关性分析。结果 1)DN的分期随FCP水平的降低而逐渐升高(x^2=43.7,P<0.001)。2)DM与DN组间年龄、体质量指数(BMI)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)差异均无统计学意义(P>0.05)。DN组病程、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、HbA1c、mA1b均显著高于DM组(P<0.01),而DN组GFR和FCP均显著低于DM组(P<0.01)。3)FCP水平与病程呈负相关(r=-0.317,P<0.01),与HDL-C及mA1b呈负相关(r=-0.201、-0.285,P<0.05);与TG和GFR呈正相关(r=0.275、0.507,P<0.01),但与年龄、空腹血糖及HbA1c无相关性(P>0.05)。结论 FCP水平与2型DN分期密切相关,2型DM患者保持生理性的C肽水平可能会延缓DN的发展。Objective To explore the correlation between fasting connecting peptide（FCP） level with Type 2 diabetic nepbropathy （DN） morbility factor in the patients with diabetes mellitus（DM）. Methods 258 patients with DM in our hospital during June of 2006 to December of 2008 were collected by retrospective analysis. 187 patients were in the group of DM and 71 in DN group, respectively. Serum FCP, glomerular filtration rate（ GFR）, total cholesterol （TC）, triglyceride （ TG）, renal function, glycosylated hemoglobin （HbAlc）, urine microalbumin （mAlb） and body mass index （BMI） were detected respectively. FCP was compared With these experiment index. Results 1）Along with the FCP level descend,The stages of DN was hoist gradually（χ2=43.7,P〈0. 001） ;2）These levels of ages,BM1,TG and HDL C were not difference between two groups,P〉0.05. These levels of course of disease,TC, LDL-C, HbA1 c and mAlb in DN group were higher than it in DM group, but GFR and CP in DN group were lower than it in DM group, there were significantly difference, P〈0.01 ;3）The serum concentration of CP was negative correlation with course of disease（r= -0.317,P〈0.01）,HDI.-C（r =-0. 201,P〈0. 05） andmAlb （r=-0. 285,P〈0. 05）. It was positive eorre- lation with TG（r=0. 275,P〈0.01） and GFR（r=0. 507,P〈0.01） ,reapectively. But there not correlation with age,fasting blood glucose and HbAlc,P〉0.05. Conclusion There is intimate correlation between FCP level with the stages of DN. Remaining physiological FCP concentration in the patients with DM may delay its development of DN.

关 键 词：C肽 糖尿病 2型 糖尿病肾病 实验室技术和方法 

分 类 号：R446.112[医药卫生—诊断学] R578.2[医药卫生—临床医学]