生物技术在喜树碱研究中的应用  

Application of Biotechnology in Research of Camptothecin

作　　者：彭志红[1] 胡家金[1] 李合松[1] 

机构地区：[1]湖南农业大学生物科学技术学院,湖南长沙410128

出　　处：《现代生物医学进展》2010年第16期3175-3177,共3页Progress in Modern Biomedicine

基　　金：校青年科学基金项目(07QN27)

摘　　要：喜树碱是从我国特有植物喜树中分离到的一种具有抗癌活性的萜类吲哚生物碱,具有重要的利用和研究价值。本文通过对喜树碱资源的现状及生物技术在喜树碱研究中的应用进行综述,指出喜树碱及其衍生物在植物体内含量甚微,远远不能满足市场的需要,阐明应用生物技术提高喜树碱含量是目前极其有效的研究手段和方法,同时对利用生物技术大量生产喜树碱的研究方向进行了展望。Camptothecin is a kind of anti-cancer activity of terpene indole alkaloids. Camptothecin has important uses and research value. The research progress on the status of camptothecin resources and the application of biotechnology on camptothecin were summarized. The author also pointed out the content of Camptothecin were little in plants and couldn＇t satisfy the needs of the market. It suggested that was the most effective research tools and methods by the application of biotechnology on eamptotheein. In addition, the future researching fields how to improve the camptothecin content was put forward.

关 键 词：喜树碱 生物技术 细胞培养 毛状根培养 

分 类 号：S18[农业科学—农业基础科学] S567