肿瘤干细胞的生物特性及其起源  

Biological characteristics and genesis of cancer stem cells

作　　者：邱文(综述)[1] 胡隆飞(综述)[1] 李洋(综述)[1] 肖岚(审校)[1] 

机构地区：[1]第三军医大学学员旅8队,重庆400038

出　　处：《国际肿瘤学杂志》2010年第7期492-495,共4页Journal of International Oncology

摘　　要：肿瘤干细胞高表达抗氧化剂谷胱甘肽而降低活性氧水平，避免DNA损伤，从而抵制放疗作用。此外抑癌基因p53导致的DNA修复异常也参与调节肿瘤干细胞的永生化。本文总结肿瘤千细胞自我更新、异质性、耐药性等生物学特性，并对肿瘤干细胞起源的正常细胞突变和细胞融合假说进行综述。Cancer stem cells is a small fraction of cells exist in cancers and own the same characteristics of stem cells. It has recently been shown that cancer stem cells in some tumours contain lower reactive oxygen species（ROS） levels and enhanced ROS dcfence radioresistance. The DNA damage induced by p53 tumor suppressor protein is associated with self cancer stem cells. We have reviewed the biological characteristics in- cluding self-renewal, drug resistance, heterogeneity and so on. As to the genesis of the cancer stem cells, some researchers believe that they arise from normal adult stem cells, progenitor cells or mutation of somatic cells, while others consider that cancer stem ceils are derived from cell fusion and so on.

关 键 词：肿瘤干细胞 细胞分化 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]