高迁移率族蛋白B1与胰腺癌的关系  

High mobility group Box-1 and pancreatic carcinoma

作　　者：贾俊英(综述)[1] 程宝泉(综述)[1] 

机构地区：[1]山东大学齐鲁医院消化内科,济南250012

出　　处：《国际肿瘤学杂志》2010年第7期539-542,共4页Journal of International Oncology

摘　　要：高迁移率族蛋白B1（HMGB1）是细胞内的非组蛋白染色体结合蛋白，在维持核小体稳定和DNA重组、复制、修复及基因转录中发挥着重要作用。而细胞外HMGB1可作为一种“晚期炎症介质”，在炎症的晚期阶段启动着炎症反应。最近研究发现，HMGB1作为一种非组蛋白染色体蛋白质，与胰腺癌的生长、浸润、转移密切相关，能促使细胞外基质降解，促进胰腺癌浸润、转移。As an intraeellular non-histone chromosomal binding protein, High mobility group Box-1 （ HMGB1 ） plays an important role in maintaining the stability of the nuclear body and DNA recombination, duplication, repair and genetic transcription. Besides, extraeelluar HMGB1 may serves as a ＂late inflammatory mediator＂, which start inflammatory response in the late stage of inflammation. Recent studies have found that, HMGB1 is closely related with the growth, infiltration and migration of pancreatic carcinoma. Also, HMGB1 can promote the degradation of extracelluar matrix, the infiltration and the migration of pancreatic carcinoma.

关 键 词：HMGB1蛋白质 胰腺肿瘤 

分 类 号：R631.02[医药卫生—外科学]