新生儿高胆红素血症血清神经元特异性烯醇化酶检测的临床意义  

Clinical significance of neuron-specific enolase in Neonatal hyperbilirubinemia serum

作　　者：金晓秋[1] 张英慧[2] 王跃辉[3] 于桂艳[4] 刘晖[5] 

机构地区：[1]齐齐哈尔医学院第二附属医院儿科,161000 [2]齐齐哈尔医学院第二附属医院神经电生理科,161000 [3]齐齐哈尔医学院第二附属医院同位素室,161000 [4]齐齐哈尔医学院第二附属医院高压氧科,161000 [5]齐齐哈尔医学院第二附属医院神经内科,161000

出　　处：《中国医疗前沿》2010年第15期60-61,共2页China Healthcare Innovation

摘　　要：目的通过检测新生儿高胆红素血症患儿血清神经元特异性烯醇化酶(NSE)的变化,探讨NSE诊断新生儿胆红素脑病的意义。方法 36名健康新生儿和96名本院新生儿室收治的高胆红素血症患者静脉采血利用化学发光法检测血清NSE水平,同时做脑干听觉诱发电位(BAEP)检测。结果 NSE异常患儿BAEP异常率在观察组与轻度升高、中度升高与重度升高各组间比较p<0.05,差异具有统计学意义。在轻度升高组与中度升高组比较p>0.05,差异无统计学意义。结论 NSE检测较BAEP测定能更早期诊断新生儿胆红素脑病。Objective To investigate the significance of neuron-specific enolase（NSE）for the diagnosis of neonatal bilirubin encephalopathy.Methods 36 healthy newborns and 96 patients with hyperbilirubinemia were detected by blood serum NSE level,while doing the brain stem auditory evoked potentials（BAEP）detection.Results BAEP abnormalities in children with abnormal rates of NSE in the observation group and slightly elevated group,moderately elevated and severely elevated in each group p 0.05,significant difference;In the slightly elevated group and moderate increase in higher group p 0.05,no significant difference.Conclusion NSE detect more early diagnosis of neonatal bilirubin encephalopathy.

关 键 词：神经元特异性烯醇化酶 新生儿胆红素脑病 脑干听觉诱发电位 早期诊断 

分 类 号：R446.11[医药卫生—诊断学] R741.04[医药卫生—临床医学]