汉语单字视觉联想脑激活的BOLD-fMRI定量分析  

Application of BOLD-fMRI Quantitive Analysis in Visual Stimulating by Single Chinese

作　　者：杨利霞[1] 贾文霄[2] 汤伟军[3] 王红[2] 丁爽[2] 王皓[2] 

机构地区：[1]上海市徐汇区中心医院影像科,200031 [2]新疆医科大学第二附属医院影像中心,830063 [3]上海华山医院放射科,200040

出　　处：《临床放射学杂志》2010年第8期1129-1132,共4页Journal of Clinical Radiology

基　　金：国家自然科学基金资助项目(编号:30760062)

摘　　要：目的运用血氧水平依赖功能磁共振成像(BOLD-fMRI)测量正常人汉语单字联想语言中枢激活体素,探讨一种简单方便的定量分析方法揭示语言中枢激活特点及便于临床操作的可行性。资料与方法采用血氧水平依赖法(BOLD)组块设计,考查11名健康受试者(汉族)接受单个汉字任务视觉刺激时的相关脑区激活特点,所得原始图像数据经神经功能影像分析软件处理进行定量分析。结果汉语单字视觉联想刺激任务主要激活了左侧额中回和额下回(BA9和BA47)、颞中回(BA37)皮层、顶上下小叶(BA7/40),双侧视觉系统(BAs17-19)及小脑有显著激活。结论汉语单字视觉联想刺激模式激活语言功能区的激活体素比较恒定,测试方法简单,便于在临床应用。Objective Bold oxygenation level dependent functional magnetic resonance imaging（BOLD-fMRI） was used to observe the activated volumes of language cortex of normal subjects and to investigate value of the quantitative analysis and the clinical reliability. Materials and Methods To determine the neuroanatomic functional brain areas responsible for single Chinese reading,blood oxygenation level dependent （BOLD）block design by 1.5T MRI was performed in 11 healthy volunteer Chinese. Results The BOLD-fMRI studies demonstrated language cortical areas. The activated areas included left lateralization of frontal（BAs 9 and 47）and temporal（BA 37）cortices and right lateralization of visual systems（BAs 17–19）,parietal lobe（BA 3）,and cerebellum. Conclusion The visual stimulating task by single Chinese is a feasible and simple imaging method for studying languages processing in the human brain.This approach is the more reasonable and steady measurement for clinical Application.

关 键 词：血氧水平依赖性功能磁共振成像 语言中枢 汉语视觉任务 定量 

分 类 号：R445.2[医药卫生—影像医学与核医学]