昆虫包涵体衍生病毒囊膜蛋白的分子生物学  

Molecular biology of the occlusion-derived virus envelope proteins

作　　者：相兴伟[1] 吴小锋[1] 

机构地区：[1]浙江大学动物科学学院,杭州310029

出　　处：《昆虫学报》2010年第7期809-817,共9页Acta Entomologica Sinica

基　　金：国家自然科学基金项目(30871827)

摘　　要：了解杆状病毒的囊膜蛋白对揭示病毒入侵、囊膜蛋白核定向转运机制以及研究控制昆虫新策略等方面具有重要意义。目前研究表明,包涵体衍生病毒(occlusion-derived virus,ODV)的囊膜蛋白包括ODV-E25,ODV-E66,ODV-E56,ODV-E18,ODV-E28,P74,PIF1,PIF2,PIF3,GP41,ODV-EC27,ODV-E35,ODV-EC43,BV/ODV-E26,P91和ORF150。本文结合国内外的研究成果系统地综述了囊膜蛋白的结构和功能,其在经口感染、调节细胞周期和囊膜蛋白的传送等方面起作用。囊膜蛋白的核定向转运机制,ODV与昆虫中肠之间和包涵体基质之间相互作用以及ODV结构蛋白之间的相互作用等将是今后的研究重点。Studies on the baculovirus envelope proteins are important to reveal the mechanism of viral entry and nuclear transporting and targeting of the envelope proteins and also fundamental for the development of new strategies for insect control. Recent researches showed that the envelope proteins of occlusion-derived virus （ODV） include ODV-E25, ODV-E66, ODV-E56, ODV-E18, ODV-E28, P74, PIF1, PIF2, PIF3, GP41, ODV-EC27, ODV-E35, ODV-EC43, BV/ODV-E26, P91 and ORF 150. This article reviewed the recent research achievements about the structure and function of the baculovirus envelope proteins. Most envelope proteins are related to per os infection, cell cycle regulation, and the trafficking of envelope proteins. The mechanism of trafficking of ODV envelope proteins, their interaction with insect midgut and the OB matrix, and the protein-protein interaction of ODV structural proteins will be the focus of future research.

关 键 词：杆状病毒 包涵体衍生病毒 囊膜蛋白 基因敲除 核定向转运 昆虫中肠 

分 类 号：Q965.8[生物学—昆虫学]