黄花败酱不同部位对小鼠镇静催眠效果的比较  

Comparison of sedative effects of different fractions from patrinia scabiosaefolia fisch in mice

作　　者：彭向东[1] 王学锋[1] 

机构地区：[1]中南大学湘雅附三医院,长沙410038

出　　处：《中国医师杂志》2010年第8期1022-1024,共3页Journal of Chinese Physician

基　　金：湖南省科技厅一般课题资助项目（2007sk3048）

摘　　要：目的 研究黄花败酱各部位的镇静催眠作用,为镇静活性部位的分离提供指导.方法 提取分离黄花败酱石油醚、乙酸乙酯、正丁醇三个部位,采用自主活动、洞板试验以及协同戊巴比妥钠催眠试验检测三个部位对小鼠的镇静效果,并与70%乙醇总提取物比较.结果 发现正丁醇部位镇静效果显著优于其它部位,且呈一定的量效关系.结论 正丁醇部位是黄花败酱镇静活性的主要部位,对此部位进行分离有望得到镇前活性好的单体物质.Objective To investigate the sedative effects of different fractions of patrinia scabiosaefolia fisch. in mice and provide some valuable information for isolating components with sedative effect.Methods Petroleum, acetic ether and n-butanol fraction was isolated from the patrinia scabiosaefolia fisch.. The sedative effects were determined with locomotor activity assay, hole board test and sodium thiopental-induced sleeping time assay, and it was compared with the effects of total 70% ethanol extract. Results N-butanol fraction showed better sedative effect compared with others, and it was in a dose-dependent manner. Conclusion The results showed that the main active principles of patrinia scabiosaefolia fisch. were the n-butanol fraction, and the promising active chemical might be obtained from this fraction.

关 键 词：败酱草/化学/药理学 清醒镇静 催眠术 

分 类 号：R285.5[医药卫生—中药学]