微量稀释法检测四种药物对白念珠菌的敏感性分析  

Observing the susceptibility of candida albicans to fluconazole terbinafine and itraconazole and nystatine by m27-a microdilution method

作　　者：宋晓晶[1] 董岩[2] 张虹[1] 郑童娇[1] 

机构地区：[1]大连医科大学附属第一医院口腔科,辽宁大连116011 [2]大连医科大学口腔医学院,辽宁大连116044

出　　处：《大连医科大学学报》2010年第4期462-464,共3页Journal of Dalian Medical University

摘　　要：[目的]探讨特比萘芬、氟康唑、伊曲康唑、制霉菌素体外抗口腔念珠菌的敏感性。[方法]采用NCCLS公布的M-27A方案微量液体稀释法分别测定特比萘芬、氟康唑、伊曲康唑、制霉菌素对38株临床分离的口腔念珠菌的体外敏感性。[结果]38株白念珠菌对氟康唑耐药4株,敏感34株;对伊曲康唑耐药5株,敏感33株;对特比奈芬耐药15株,敏感23株;制霉菌素均敏感。[结论]4种药物中氟康唑的敏感性相对较高,但仍有耐药现象,且氟康唑与伊曲康唑存在交叉耐药。[Objective] To compare the susceptibility of candida albicans cultured with fluconazole,terbinafine,itraconazole and nystatine.[Methods] M27-A Microdilution Method based on NCCCLS was used to determine the susceptibility of 38 candida albicans isolates cultured with fluconazole,terbinafine,itraconazole and nystatine.[Results] Four fluconazole-resistance isolates,34 susceptible isolates,5 itraconazole-resistance isolates,33 susceptible isolates,15 terbinafine-resistance isolates and 23 susceptible isolates were detected from 38 clinical candida albicans isolates.[Conclusion] The susceptibility of candida albicans to fluconazole is the highest in the 4 drugs,but the resistance to fluconazole and cross-resistance between fluconazole and itraconazole are found in this study.

关 键 词：口腔念珠菌 氟康唑 伊曲康唑 特比萘芬 制霉菌素 

分 类 号：R446.5[医药卫生—诊断学]