复方丹参注射液治疗急性胰腺炎的临床研究  

The Clinical Study on CO. Salvia Miltiorthizae. Injection in the Treatment of Actute Pancreatitis

作　　者：张锦棠[1] 邹劲林[1] 朱金彩[1] 

机构地区：[1]中山大学附属第五医院,珠海519000

出　　处：《中国临床实用医学》2010年第9期28-30,共3页China Clinical Practical Medicine

摘　　要：目的观察复方丹参注射液在治疗急性胰腺炎中的临床疗效，了解复方丹参注射液对急性胰腺炎（AP）患者血浆内皮素（ET）浓度的影响，对改善微循环的作用。方法将100例AP患者随机分为对照组（40例）和治疗组（60例），对照组采用常规治疗，治疗组采用常规治疗＋复方丹参注射液治疗，以放射免疫法（RIA）测定血浆ET浓度。结果两组病例除了腹痛消失时间无显著性差异外（P〉0．05），腹部压痛消失、血尿淀粉酶、影像学恢复和平均治疗时间治疗组均短于对照组（P〈0．05）。治疗7d后，对照组患者血浆ET浓度与治疗前比较无显著性差异；治疗组患者治疗后血浆ET浓度[（61．89±7．14）ng／L]显著低于治疗前[（104．41±7．88），P〈0．05]。结论在常规治疗的基础上应用复方丹参注射液治疗急性胰腺炎可以使患者微循环状态得到改善，具有良好的临床疗效。Objective To study clinical effects of CO. Salvia Mihiorthizae（CSM） on Actute Pancreatitis, the changes of plasma endothelin （ET） as well as the role on the microcirculation of patients with acute pancreatitis（AP）. Methods A total of 100 patients with AP was divided into contrast group （ group A） （ n = 40） and treat treatment group （ group B ） （ n = 60 ）, treated with routine method （ group A） and CO. Salvia Miltiorthizae, injection added routine method, respectively. The levels of plasma ET were measured by radioimmunoassay. Results The average time of abdomen tenderness, amylase and shape resume natural and treatment were significantly shorter in group B than in group A, but the average time of bellyache evaporating were not significantly differential in the two groups. After 7 days treatment, the levels of ET in group A were slightly decreased compared with those before treatment （ P 〉 0. 05 ）, while the levels of ET in group B were obviously decreased compared with those be fore treatment[ （61.89 ±7. 14） ng/L vs （104. 41 ±7. 88） ng/L,P 〈0. 05]. Conclusion CSM and apply routine treatment used at the same time to treat AP can improve microcirculation disorder in pathogenesis of AP. There were well clinical effects.

关 键 词：急性胰腺炎 内皮素 复方丹参注射液 

分 类 号：R259[医药卫生—中西医结合] R57[医药卫生—中医内科学]