蒙古族原发性高血压患者血尿酸水平与早期肾损害的关系  

Relationship between serum uric acid level and renal injury in early stage in Monglian patients with essential hypertension

作　　者：贺文帅[1] 赵兴胜[1] 温霞[1] 苏布道[1] 

机构地区：[1]内蒙古自治区医院心内科,010017

出　　处：《中国临床实用医学》2010年第9期53-55,共3页China Clinical Practical Medicine

基　　金：内蒙古自治区科技厅项目

摘　　要：目的探讨蒙古族原发性高血压患者血尿酸水平与早期肾损害的关系和可能机制。方法选择蒙古族高血压患者86例，汉族高血压患者89例，分别采用尿素酶法测定血尿酸（UA）免疫比浊法测定胱抑素C（Cys-C）、13：微球蛋白（β2m），进行比较分析。结果蒙古族高血压组UA（456．32±45．49）μmol／L显著高于汉族高血压组（456．32±45．49）比UA（385．30±37．85）μmol／L（P〈0．05）。蒙古族组及汉族组UA与Cys·C、β2m均呈正相关（r=0．714、0．694；r=0．624、0．526；P〈0．05），在Cer〈50ml／min时，Cer与Ca（r=0．72）、Cys—C（r=0．68）、β2m（r=0．75），SCr（r=0．65）均有较好相关性呈正相关，r分别为0．72、0．68、0．75、0．65。Ccr为50～80ml／min时，Cer与UA、Cys．C、β2m的相关性，r分别为0．75、0．73、0．70，而Cer与SCr的r值为0．55。结论 蒙古族高血压人群高尿酸血症患者更容易出现肾损害。Objective To discuss the relationship and possible mechanism between serum uric acid level and renal injury in early stage in Monglian patients with essential hypertension. Methods The patients with high blood pressure were chosen as the subjets,which the Mongolian patients were 86 cases and Han 89 cases. They were separately detected UA in the method of urease and Cys-C, 132 m in the way of turbidimetric immunoassay. The data concerned were compared with each other. Results In Mongolian patients group with high- blood pressure,the rate of uric acid was （456. 32 ±45.49）μmol/L; that of Han patients group was （385.30 ± 37.85 ） μmol/L. The rate of uric acid between Mongolian group and Han group showed apparent difference （ P 〈 0. 05 ）. UA showed positive correlation with Cys-c （r = 0. 714,0. 694, P 〈 0. 05 ）while UA showed positive correlation with 132 m（r =0. 624,0. 526,P 〈0. 05）in the Mongolian group and in the Han group. CCr showed correlation with UA,Cys-c, 132 m when CCr 〈 50 ml/min, r was 0. 72,0. 68,0. 75,0. 65 respectively; CCr showed correlation with UA ,Cys-e, 132 m when CCr was 50-80 ml/min, r was 0. 75,0. 73,0. 70. CCr showed correalation with SCr,r was 0. 55. Conclusion Those Mongolian patients with hypertension were more likely to show the symptoms of renal injury and metabolic disorder.

关 键 词：蒙古族 高血压 血尿酸 肾损害 

分 类 号：R544.1[医药卫生—心血管疾病]