指状青霉提取物诱发大鼠肺及肝原代细胞DNA损伤作用  

The Effect of Extract from Penicillium Digitatum on the Induced DNA Damage in the Primary Cells of the Lungs and liver of Rat

作　　者：杨胜利[1] 于国强[1] 赵国强[2] 陈米朝 韩绍印[1] 丁兰萍[1] 宋爱云[1] 宫亚欧[1] 

机构地区：[1]河南医科大学食管癌研究室 [2]河南大微生物与免疫学教研室 [3]新密市第一人民医院

出　　处：《河南肿瘤学杂志》1999年第2期95-97,共3页Henan Journal of Oncology

基　　金：河南省卫生厅资助

摘　　要：目的探讨指状青霉（Penicilliumdigitatum）提取物对大鼠肺及肝原代细胞的DNA损伤作用。方法用指状青霉提取物诱发大鼠肺及肝原代细胞的程序外DNA合成（UDS）。结果指状青霉提取物均可诱发大鼠肺及肝原代细胞的UDS，尤其是对肺原代细胞的作用更为明显（P＜0.01）。结论指状青霉提取物对大鼠肺及肝原代细胞DNA有损伤作用，从而证实其对哺乳动物细胞具有明显的遗传毒性。Objective To probe into the effect of extract form Penicillium digitatum on the induced DNA damage byin the primary cells of the lungs and liver of rat. Methods Unscheduled DNA synthesis (UDS) in the primary cells of thelungs and liver of rat.Results The extract could induce UDS in the primary cells of the lungs and liver of rat, and UDS was particularly obvious in the primary cells of the lungs. Conchusion The finding indicated that the extract has the effect of heredo-toxicity on the cells of the mammals.

关 键 词：指状青霉 原代细胞 程序外DNA合成 遗传毒性 

分 类 号：R996[医药卫生—毒理学] R992[医药卫生—药学]