一氧化氮对小肠消化间期移行性复合运动作用的研究  

The role of nitric oxide during the small intestinal migrating motor complex

作　　者：吴建维[1] 罗金燕[1] 龚均[1] 蒋予[1] 

机构地区：[1]西安医科大学第二临床医学院

出　　处：《中华消化杂志》1999年第2期82-84,共3页Chinese Journal of Digestion

摘　　要：目的研究一氧化氮（ＮＯ）在小肠消化间期移行性复合运动（ＭＭＣ）控制中的作用。方法在大鼠十二指肠、空肠分别埋置应变片，在动物清醒的状态下分别记录空腹和餐后静脉输注ＮＧ硝基Ｌ精氨酸甲酯（ＬＮＡＭＥ）、Ｌ精氨酸、Ｄ精氨酸、硝普钠和血管紧张素Ⅰ后十二指肠和空肠压力变化。结果在餐后注入一氧化氮合酶抑制剂ＬＮＡＭＥ，可诱发类似空腹状态下的ＭＭＣ运动形式；注入ＮＯ供体硝普钠，则中断空腹时的小肠ＭＭＣ周期，诱发进食后小肠运动形式；Ｌ精氨酸和ＬＮＡＭＥ同时输注，消除ＬＮＡＭＥ的作用，而Ｄ精氨酸无此作用。单独输注Ｌ精氨酸、Ｄ精氨酸或血管紧张素Ⅰ对小肠ＭＭＣ没有影响。结论小肠神经系统ＮＯ紧张性分泌的调节，可能与小肠消化间期和消化期之间小肠运动形式的转换有关，ＮＯ释放增加可导致Ⅱ相时间变长，中断或延长ＭＭＣ；抑制ＮＯ合成与小肠消化间期运动形式的产生有关。Objective To elucidate the role of nitric oxide (NO) during the small intestinal migrating motor complex (MMC).Methods Rats were implanted with strain gauges in the duodenum and jejunum to recording the motor action of the small intestine in fasting and postprandial states after intravenous infusion of N G Nitro arginine methyl ester(L NAME), L arginine, D arginine, sodium nitroprusside(NaNP) and angiotensin Ⅰ,respectively. Results Intravenous infusion of L NAME, a NO synthase inhibitor, induced a MMC pattern of the fasting state of the rats. Infusion of NaNP, a NO donor, disrupted small intestinal MMC in fasting rats inducing a pattern of postprandial state. Both fasting and postprandial, infusion of L NAME shortened the duration of phase Ⅰand phase Ⅱ, but didn't change the duration, frequency, amplitude and speed of propagation of phase Ⅲ. L arginine, but not D arginine, infused together with L NAME prevented the effect of L NAME infusion. Infusion of L arginine, D arginine or angiotensin I alone didn't modify the small intestinal motor pattern. Conclusion An inhibition of NO synthesis may be involved in the initial MMC motor pattern during fasting, whereas an increase of NO output is related to the occurrence of the postprandial motor pattern.

关 键 词：肌电复合波 移行 小肠 一氧化氮 L-NAME 

分 类 号：R333.3[医药卫生—人体生理学]