针药合用治疗乙肝失代偿性肝硬化临床观察  

Clinical Observation of Hepatitis B Combination Decompensated Liver Cirrhosis which Treated by Acupuncture Combined with Drugs

作　　者：英健民[1] 

机构地区：[1]柳州市中医院,广西柳州545001

出　　处：《辽宁中医药大学学报》2010年第9期155-157,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察针药合用对乙肝失代偿期肝硬化门静脉高压症患者的临床疗效。方法:将114例乙肝失代偿肝硬化患者随机分成针药合用治疗组(简称治疗组)57例,对照组57例。对照组予阿德福韦酯治疗,并予常规支持、对症处理,治疗组在此基础上加用中药配合针灸治疗,10周为1个疗程,共治疗3个疗程。观察治疗前后HBV-DNA、肝功能、门静脉血液流变学指标门静脉内径(DPV)、脾静脉内经(DSV)和门静脉最大血流速度(PVX)、脾静脉最大血流速度(SVX)、门静脉血流量(PVF)、脾静脉血流量(SVF)、肝纤维化指标透明质酸(HA)、III型前胶原(PCIII)、层黏蛋白(LN)、IV型胶原(CIV)以及临床症状积分的变化。结果:治疗组总有效率为92.7%,对照组总有效率为78.9%,治疗组有效率显著优于对照组(P<0.05),治疗组治疗后与治疗前相比DPV、DSV、PVF、SVF显著降低(P<0.01),HA、CIV、临床症状积分显著下降(P<0.05);治疗组治疗后较对照组治疗后相比PVF、SVF显著降低(P<0.01),DSV、HA、CIV、临床症状积分亦显著降低(P<0.05)。结论:针药合用具有降低肝硬化门静脉高压的作用。Objective：To observe the Clinical effect of acupuncture combined with drugs treating patients with decompensated hepatitis B cirrhosis and portal hypertension.Methods：The 114 cases of hepatitis B patients with decompensated cirrhosis were randomly divided into 57 cases of acupuncture combined with drugs treatment group（treatment group for short）,and 57 cases of the control group.Control group treated by adefovir,the general support for treatment,and symptomatic treatment.The treatment group was based on that of control group,and combined with traditional chinese medicine and acupuncture treatment.10 weeks as a course of treatment,treated for 3 courses.Observed the changes before and after treatment which contained HBV-DNA,liver function,portal vein blood rheology indices：diameter of portal vein（DPV）,diameter of splenic vein（DSV）and maximum portal vein flow rate（PVX）,maximum splenic vein flow rate（SVX）,portal vein flow（PVF）,splenic venous flow（SVF）,liver fibrosis,hyaluronic acid（HA）,procollagen III（PCIII）,laminin（LN）,collagen IV（CIV）,and clinical integration.Results：The total effective rate was 92.7% in the treatment group,78.9% in the control group,treatment group was significantly better than the control group（P〈0.05）,DPV,DSV,PVF,SVF in treatment group were significantly lower compared with that before treatment（P〈0.01）,HA,CIV,clinical symptom scores decreased significantly（P〈0.05）;PVF,SVF in the treatment group were significantly lower than that in the control group after treatment（P〈0.01）;DSV,HA,CIV,clinical symptom scores decreased significantly（P〈0.05）.Conclusion：Treatment of acupuncture combined with drugs played a role of reducing portal hypertension of liver cirrhosis.

关 键 词：失代偿期肝硬化 门静脉高压症 针灸 中药 疗效观察 

分 类 号：R657.31[医药卫生—外科学]