4-二甲胺基吡啶催化美欧卡霉素的合成  

SYNTHESIS OF MIOCAMYCIN BY USING 4DIMETHYL AMINOPYRIDINE (DMAP) AS ACYLATION CATALYST

作　　者：刘小平[1] 

机构地区：[1]湘潭工学院化工系

出　　处：《湘潭大学自然科学学报》1999年第2期73-75,共3页Natural Science Journal of Xiangtan University

摘　　要：由麦迪霉素Ａ直接酰化合成美欧卡霉素Ｃ具有工艺简便的特点．但用吡啶、Ｎ，Ｎ二乙基苯胺等普通催化剂，难以获得良好的效果．采用高效酰化催化剂——４二甲胺基吡啶（ＤＭＡＰ）催化直接酰化过程，反应在较低温度下完成，避免高温引起的分子内异构化。The process that Miocamycin (C) is synthesized from Midecamycin (A) by direct acylation eases operation, but result of reaction with acetic anhydride and pyridine is dissatisfactory. This paper describs direct acylation of Midecamyain (A) with 4dimethyl aminopyridine and acetyl chloride at lower temperature. The yield and purity of product are satisfactory.

关 键 词：美欧卡霉素 合成 酰化 催化 二甲胺基吡啶 

分 类 号：TQ465.2[化学工程—制药化工]