复合稳定剂增加脊髓灰质炎糖丸疫苗的稳定性  

Increase Of Stability Of Oral Poliovaccine By Combined Stabilizer

作　　者：姜述德[1] 管正德[1] 吴炳元[1] 唐桂珍[1] 王燕[1] 李映波[1] 

机构地区：[1]中国医学科学院中国协和医科大学医学生物学研究所

出　　处：《云南大学学报（自然科学版）》1999年第3期216-218,共3页Journal of Yunnan University(Natural Sciences Edition)

摘　　要：该研究改进了现行脊髓灰质炎糖丸疫苗的稳定性，由１ｍｏｌ·Ｌ－１ＭｇＣｌ２稳定性改为１ｍｏｌ·Ｌ－１ＭｇＣｌ２＋０．５ｍｏｌ·Ｌ－１磷酸盐缓冲液复合稳定剂（１ｍｏｌ·Ｌ－１ＭｇＣｌ２＋０．５ｍｏｌ·Ｌ－１ＰＢ）．采用复合稳定剂后，大大增加了疫苗的稳定性．２２℃保存时间比１ｍｏｌ·Ｌ－１ＭｇＣｌ２稳定剂延长了一周，即保存时间从１２ｄ延长至１８～２１ｄ．疫苗于４℃保存了６个月，滴度降低甚微．在３７℃保存３ｄ。Stabilizer use at present for candy poliovaccine was improved.It is changed fro m 1?mol·L -1 MgCl 2 to a combined one consisting of 1?mol·L -1 Mg Cl 2 plus 0.5?mol·L -1 phosphate buffer. The viccine stability is greatly increased by the combined stabilizer.The effec tive period of storage of viccine in combined stabiliger 22℃ is 1 week longer than that in 1?mol·L -1 MgCl 2,that is from 12?d to 18 21 days.Th ere is only a little drop of virus titre after storage of 6 months at 4℃.The titer drop of viccine meets WHO requirements after storage of 3?d t 37℃.

关 键 词：脊髓灰质炎糖丸疫苗 热稳定性 复合稳定剂 

分 类 号：R392－33[医药卫生—免疫学] R512.401[医药卫生—基础医学]