Biocompatibility of Surface-Modified Biphasic Calcium Phosphate/Poly-L-Lactide Biocomposite in vitro and in vivo  

作　　者：Weizhong Yang Guangfu Yin Dali Zhou Jianwen Gu Yadong Li Hujun Zhang 

机构地区：[1]College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China [2]Chengdu Military General Hospital, Chengdu 610083, China

出　　处：《Journal of Materials Science & Technology》2010年第8期754-758,共5页材料科学技术（英文版）

基　　金：supported by Doctoral Fund of Ministry of Education of China under grant No.20060610024

摘　　要：The biocompatibility of surface-modified biphasic calcium phosphate （mBCP）/poly-L-Lactide （PLLA） biocomposite was investigated through a series of experiments in vitro and in vivo. Acute toxicity and short term systemic toxicity experiments revealed no toxicity of the materials. Hemolysis assay indicated the good blood compatibility of the composite. In cytotoxicity assay, L929 mouse fibroblasts could well differentiate and proliferate. Animal experiments in vivo were.performed by implanting the materials into rabbits muscle for 8 weeks. The decreasing of inflammatory cells, the building of fibrous tissue layer as well as the growing of blood cells into materials indicated the nontoxicity of the composite. Based on the experiment results, surfacemodified BCP/PLLA biocomposite is proven to have superior biocompatibility, which would be a promising bone repairing material.The biocompatibility of surface-modified biphasic calcium phosphate （mBCP）/poly-L-Lactide （PLLA） biocomposite was investigated through a series of experiments in vitro and in vivo. Acute toxicity and short term systemic toxicity experiments revealed no toxicity of the materials. Hemolysis assay indicated the good blood compatibility of the composite. In cytotoxicity assay, L929 mouse fibroblasts could well differentiate and proliferate. Animal experiments in vivo were.performed by implanting the materials into rabbits muscle for 8 weeks. The decreasing of inflammatory cells, the building of fibrous tissue layer as well as the growing of blood cells into materials indicated the nontoxicity of the composite. Based on the experiment results, surfacemodified BCP/PLLA biocomposite is proven to have superior biocompatibility, which would be a promising bone repairing material.

关 键 词：BIOCOMPATIBILITY Biphasic calcium phosphate （BCP） Poly-L-Lactide （PLLA）biocomposite 

分 类 号：TQ174.75[化学工程—陶瓷工业] TB332[化学工程—硅酸盐工业]