钩端螺旋体蛋白质组学研究进展  

Advances of leptospiral proteomics research

作　　者：曾令兵[1] 张云怡[1] 秦金红[1] 

机构地区：[1]上海交通大学医学院病原生物学教研室,200025

出　　处：《国际流行病学传染病学杂志》2010年第4期276-278,共3页International Journal of Epidemiology and Infectious Disease

摘　　要：钩端螺旋体病是一种世界范围内流行的人兽共患传染病，临床表现复杂多变，主要表现为肝肾肺的损伤。目前，在钩端螺旋体病的诊断和预防方面，都缺乏较好的候选抗原。与此同时，在基因水平研究钩端螺旋体的致病机制又存在一定的困难。蛋白质组学是从整体水平研究生物体蛋白质组成的一门学科。闳此，钩端螺旋体的研究可以从其蛋白质组水平，借助蛋白质组的研究手段和方法去发掘新的诊断技术和疫苗候选抗原，以及阐明钩端螺旋体的致病机制。Leptospirosis is a worldwide zoonotic disease, and its clinical manifestations are complexity, which mainly shows the damage of liver, kidney and lung. Until now, limits antigens can be employed in diagnosis and prevention. Meanwhile, there are many troubles in getting the pathogenesis of Leptospira through genetic manuplation. Proteomics is one of the system biology which study the protein composition of organism. Therefore, employed methods of proteomics is a new way to get new antigens of diagnosis and vaccine, and acquire the pathogenic mechanisms of Leptospira .

关 键 词：钩端螺旋体 蛋白质组学 疫苗 诊断 致病机制 

分 类 号：R514.4[医药卫生—内科学]