甲型肝炎病毒与过敏性哮喘的互作关系  

Relations between hepatitis A virus and asthma

作　　者：何方[1] 何卓晶[2] 银国利[1] 洪艳[2] 陈勇[1] 

机构地区：[1]浙江医学高等专科学校免疫与病原生物学教研室,杭州310053 [2]浙江省医学科学院生物工程研究所,杭州310013

出　　处：《国际流行病学传染病学杂志》2010年第4期283-285,共3页International Journal of Epidemiology and Infectious Disease

摘　　要：为研究哮喘的易感基因,科学家们发现了一个新的基因家族--Tim基因家族,而生物信息学研究发现人Tin1就是人甲型肝炎病毒细胞受体（huHAVcr-1）,另外,流行病学调查结果显示甲型肝炎病毒（HAV）感染下降与哮喘发病上升这一反转现象.此文就HAV感染对哮喘的影响,以及HAV-Tim1途径对T细胞分化的作用等方面研究进展进行综述.The search for susceptible gene of asthma has led to the identification of a novel T cell immunoglobulin domain, mucin-like domain （Tim） gene family, and human Timl was initially identified as the cellular receptor for hepatitis A virus（huHAVcr-1 ）. This is intriguing, as several epidemiological studies have noted that infection with hepati- tis A virus is associated with protection against the development of asthma in human. The influence of HAV infection to asthma and the effect of HAV-Tim in T cell differentiation are reviewed in this article.

关 键 词：肝炎病毒 甲型 哮喘 Tim基因家族 受体 

分 类 号：R51[医药卫生—内科学]