Asymmetric synthesis of Anomala Osakana Pheromone isomer using protecting group free strategy  

作　　者：LINLi, LIA-Ni ZHAO QingYang YANG FanZhi YIN Wen WANG Rui 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China

出　　处：《Chinese Science Bulletin》2010年第25期2811-2813,共3页

基　　金：supported by the National Natural Science Foundation of China (20772052)

摘　　要：The protecting group free synthesis of Anomala Osakana Pheromone isomer has been achieved with high enantioselectivity (92% ee). A chiral γ-hydroxy-α, β-acetylenic ester was used as the key intermediate, which was obtained via asymmetric alkynylation of aldehyde. This was followed by readily handled selective hydrogenation and lactonization in three steps with a high overall yield (86%).The protecting group free synthesis of Anomala Osakana Pheromone isomer has been achieved with high enantioselectivity （92% ee）. A chiral y-hydroxy-α, β-acetylenic ester was used as the key intermediate, which was obtained via asymmetric alkynylation of aldehyde. This was followed by readily handled selective hydrogenation and lactonization in three steps with a high overall yield （86%）.

关 键 词：保护基 异构体 信息素 不对称 免费 合成 铜绿 对映选择性 

分 类 号：O621.3[理学—有机化学] O613.71[理学—化学]