A soluble polymer-supported NADH model:Synthesis and application  

作　　者：MEI LianRui ZHU Xiao-Qing CHENG Jin-Pei 

机构地区：[1]Department of Chemistry and the State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

出　　处：《Chinese Science Bulletin》2010年第25期2824-2828,共5页

基　　金：supported by the National Basic Research Program of China (2004CB719905);the National Natural Science Foun-dation of China (20832004,20472038,20721062 and 20672060);the 111 Project (B06005)

摘　　要：A polyethylene glycol (PEG)-supported NADH model as a novel organic reductant was designed and synthesized. The reductions of various α,β-unsaturated ketones by the PEG-supported NADH model were examined,and the results showed that the reductions completely and quickly proceed with no catalyst at ambient temperature. The main advantages of this liquid-like PEG-supported NADH model are easy workup,and an optimal potential for recycling use and solvent-free for use in reactions.A polyethylene glycol （PEG）-supported NADH model as a novel organic reductant was designed and synthesized. The reductions of various α, β-unsaturated ketones by the PEG-supported NADH model were examined, and the results showed that the reduc- tions completely and quickly proceed with no catalyst at ambient temperature. The main advantages of this liquid-like PEG-supported NADH model are easy workup, and an optimal potential for recycling use and solvent-free for use in reactions.

关 键 词：辅酶模型 可溶性聚合物 合成 应用 聚乙二醇 有机还原剂 NADH 环境温度 

分 类 号：TQ426.65[化学工程] Q552[生物学—生物化学]