人类白细胞抗原Ⅱ类基因与溃疡性结肠炎的关系研究进展  

Human Leukocyte Antigen Class Ⅱ Gene and Ulcerative Colitis

作　　者：何玉环[1] 高峰[2] 

机构地区：[1]新疆医科大学,乌鲁木齐830054 [2]新疆自治区人民医院消化内科,乌鲁木齐830001

出　　处：《医学综述》2010年第17期2604-2606,共3页Medical Recapitulate

摘　　要：溃疡性结肠炎(UC)是一种与遗传、免疫、环境等多种因素相关的慢性肠道非特异性炎症性疾病。其具体病因、发病机制还不完全清楚,但近来一系列研究表明其发生与基因多态性所致的遗传易感性相关。人类白细胞抗原Ⅱ类基因是一个引人注意的UC易感基因,具有高度多态性,与UC发病及临床表型有关,现就人类白细胞抗原Ⅱ基因与UC的相关性研究进展予以综述。Ulcerative colitis（UC）is a chronic,nonspecific inflammatory bowel disease,caused by a complex interplay of genetic,environmental and immunologic factors.The precise mechanisms underlying the etiology and pathogenesis of UC still remains unclear.However,a series of recent researches have shown that a genetic predisposition,through the inheritance of a number of contributory genetic polymorphisms,contributes to the pathogenesis of UC.Human leukocyte antigen（HLA）class Ⅱ alleles is an attractive candidate susceptible gene for UC,with a high polymorphism.It has been implicated in determining the pathogenesis and the clinical phenotype of UC as one of the hot spots in current researches.This review focuses on the recent insights into the association between UC and human leukocyte antigen（HLA）class Ⅱ genes.

关 键 词：人类白细胞抗原Ⅱ类基因 溃疡性结肠炎 基因多态性 易感基因 

分 类 号：Q343.17[生物学—遗传学] R547.62[医药卫生—心血管疾病]