炎性介质与重症急性胰腺炎肺损伤  

Inflammatory Mediators and Severe Acute Pancreatitis Complicated with Lung Injury

作　　者：吴鑫[1] 赵国海[1] 

机构地区：[1]皖南医学院弋矶山医院急诊外科,安徽芜湖241001

出　　处：《医学综述》2010年第17期2607-2611,共5页Medical Recapitulate

摘　　要：急性肺损伤是重症急性胰腺炎最常见的并发症之一,其病理生理机制尚未明确。近年来的研究发现白介素、肿瘤坏死因子α、氧自由基、磷脂酶A2、血小板活化因子、血栓素A2、内皮素、高迁移率族蛋白B1、白血病抑制因子、一氧化氮等炎性介质,通过彼此的相互作用和影响,在重症急性胰腺炎相关肺损伤进程中起着重要作用。这方面的研究进展为制定有效的防治措施提供了可靠的理论依据。Acute lung injury（ALI）is one of the most common complications of severe acute pancreatitis（SAP）,whereas its mechanisms are still unclear.In recent years,the studies showed that the inflammatory mediators,such as interleukin,tumor necrosis factor-α,oxygen free radical,phospholipase A2,platelet activating factor,thromboxane A2,endothelin,high mobility group box1 protein,leukemia inhibitory factor,and nitric oxide played an important role in the process of SAP associated with lung injury through the interactions.These researches provide the theoretical basis for the effective prevention and treatment of SAP.

关 键 词：炎性介质 重症急性胰腺炎 急性肺损伤 

分 类 号：R657.5[医药卫生—外科学]