普卢利沙星片治疗急性细菌性感染临床研究  

Clinical Study of Prulifloxacin Tablet for the Treatment of Acute Bacterial Infections

作　　者：杨静[1] 葛庚芝[1] 夏天[2] 

机构地区：[1]天津医科大学第二医院呼吸科,天津300211 [2]天津医科大学第二医院肾内科,天津300211

出　　处：《医学综述》2010年第17期2688-2690,共3页Medical Recapitulate

摘　　要：目的评价国产普卢利沙星片治疗呼吸道感染和泌尿道感染的临床疗效和安全性。方法试验药为国产普卢利沙星片,对照药为左氧氟沙星片,给药方法均为每天2次口服,200mg/次,疗程5～12d。结果两组的临床疗效间差异无统计学意义(P>0.05),试验组和对照组的临床有效率分别为95.65%和90.91%。试验组细菌清除率为95.00%(19/20),对照组为88.89%(16/18)。试验组和对照组不良反应发生率分别为12.50%(3/24)和4.35%(1/23),差异无统计学意义(P>0.05)。结论国产普卢利沙星治疗呼吸道感染和泌尿道感染安全、有效。Objective To evaluate the clinical efficacy and safety of prulifloxacin in the treatment of respiratory tract and urinary tract bacterial infections.Methods Prulifloxacin tablets were given for the treatment of mild and medoerate acute bacterial infections,whereas levofloxacin tablets were given as comparative medications.Both drugs were administered at the dosage of 200mg,per os and q12h,for 5~12 d.Results Prulifloxacin and levofloxacin showed no statistically significant difference in clinical effectiveness（P0.05）,with the clinical effective rates of 95.65% and 90.91%.The overall bacterial eradication rates were 95.00%（19/20）and 88.89%（16/18）,The incidence rates of adverse effects were 12.50%（3/24）and 4.35%（1/23）,showing no statistically significant difference（P0.05）.Conclusion Domestic prulifloxacin was a safe and effective antibiotic in the treatment of acute respiratory tract as well as urinary tract infections.

关 键 词：普卢利沙星 左氧氟沙星 细菌感染 

分 类 号：R515[医药卫生—内科学]