大鼠骨骼肌静力性负荷所致损伤过程中肌细胞能量代谢的变化  

Changes of Energy Metabolism in the Skeletal Muscle of Rats in Injury Induced by the Dynamic Load

作　　者：陈晓光[1] 刘晔[2] 

机构地区：[1]河南师范大学体育学院,河南新乡453007 [2]北京体育大学运动解剖学教研室,北京100084

出　　处：《成都体育学院学报》2010年第9期65-68,共4页Journal of Chengdu Sport University

基　　金：河南省教育厅自然科学基金项目(2008B890008);河南师范大学青年科学基金项目(2008qk26)

摘　　要：通过采用骨骼肌静力性负荷损伤动物模型,观察在所致损伤过程中肌糖原含量、骨骼肌线粒体ATP酶活性以及骨骼肌胞浆和血清中乳酸含量的变化,来探讨肌细胞能量代谢变化与骨骼肌静力性负荷所致损伤的关系。结果表明,肌细胞能源物质耗竭、能量供应不足以及糖类氧化不足所引起的三羧酸循环中介物缺乏并非导致骨骼肌静力性损伤的直接原因,肌细胞内乳酸等代谢产物堆积产生的毒副作用可能是引起骨骼肌静力性损伤的重要因素。The animal model of injury induced by the dynamic load of skeletal muscle is used to observe changes of muscle glycogen, ATP activity of muscle mitochondria, cytoplasmic and lactic acid of serum of injury to discuss the relation between change of energy metabolism of skeletal muscle cell and injury induced by dynamic load of skeletal muscle. Results show that TAC resulting from energy material depletion, unbalanced energy supply and carbohydrate oxidative insufficiency is not the direct cause of injury of dynamic load and the important factor accounting for injury of dynamic load is likely to be the side - effect produced by metabolite accumulated through lactic acid of muscle cell.

关 键 词：骨骼肌细胞 静力性损伤 能量代谢 

分 类 号：G804.2[文化科学—运动人体科学]