孕早期弓形虫抗体检测的临床意义初探  

Clinical significance of anti-Toxoplasmosis antibody in early pregnancy

作　　者：张立娟[1] 

机构地区：[1]航空工业中心医院检验科,北京100012

出　　处：《检验医学与临床》2010年第17期1848-1850,共3页Laboratory Medicine and Clinic

摘　　要：目的综合系列血清弓形虫抗体检测结果分析孕早期孕妇弓形虫感染状况。方法采用酶联免疫吸附法检测2083例妊娠早期(第6～12周)妇女血清中弓形虫抗体IgG和IgM,于2～3周后再采集IgG或IgM阳性受检者血清定量检测IgG并比较IgG滴度变化;如果IgG滴度变化小于30%或阴性于2周后再采集标本定量检测IgG。结果 1928例IgG-和IgM-,未感染弓形虫,属易感人群;其余受检者按计划再采集血清定量检测IgG。在27例IgG-和IgM+的受检者中,检出11例IgG抗体阳性,为近期原发感染;其余16例未检出IgG抗体,IgM为假阳性,未感染弓形虫,属易感人群。83例IgG+和IgM-受检者中,检出1例IgG抗体滴度升高大于30%,但未产生IgM,属近期活动性感染;其余82例IgG抗体滴度没有明显变化,属既往感染。45例IgG+和IgM+受检者中,其中14例IgG抗体滴度升高大于30%,属近期活动性感染;其余31例IgG抗体滴度没有明显变化,属既往感染,但IgM持续存在。弓形虫感染率为6.67%,其中既往感染113例,近期活动性感染26例。结论综合系列血清弓形虫抗体IgG与IgM检测,可以辅助诊断孕早期妇女弓形虫的感染状况。Objective To analyze toxoplasma infection of women in early pregnancy by anti-toxoplasmosis antibody test in surem.Methods IgM and IgG antibody of toxoplasma of 2 083 pregnant women in early pregnancy were assessed by ELISA.The serums were collected again from the pregnant women with the results of IgM＋ or IgG＋ after 2-4 weeks,and IgG wae assessed again.If the change of IgG titer was less then 30% or negative,the serums were collected after 2 weeks and IgG was assessed over again.Results There were 1 928 pregnant women with the result of IgM-and IgG-,who were susceptible population.Among 27 women with IgG-and IgM＋,11 cases were found with IgG＋,who were primarily infected,and 16 cases were not found with IgG antibody and the IgM antibody was false positive in them,who were not infected with toxoplasma and belonged to usceptible population;Among 83 women with IgG＋ and IgM-,1 case was found with the titer of IgG＋ increasing 30%,who were infected in the recent activity,and 82 cases were found with the titer of IgG＋ increasing less 30%,who were infected in the past;Among 45 women with IgG＋ and IgM＋,14 cases were found with the titer of IgG＋ increasing above 30%,were infected recently,and 31 cases were found with the titer of IgG＋ increasing less 30%,who were infection in the past.The infection rate was 6.67%,which included 4.56% of past infection and 1.25% of activity infection.Conclusion Anti-toxoplasmosis antibody test may be helpful in diagnosis of pregnant women infected with toxoplasma.

关 键 词：孕早期妇女 弓形虫 感染 抗体 

分 类 号：R446.62[医药卫生—诊断学]