兔蓝斑下核内注入6-羟基多巴胺后视前区阿片受体的变化  

CHANGE OF PREOPTIC OPIATE RECEPTORS AFTER INJECTION OF 6-OHDA INTO SUBLOCUS COERULEUS IN THE RABBIT

作　　者：朱津民[1] 何晓平[1] 李宽(女严)[1] 黄登凯[1] 曹小定[1] 

机构地区：[1]上海医科大学神经生物学教研室

出　　处：《生理学报》1990年第2期114-120,共7页Acta Physiologica Sinica

基　　金：上海市科学技术发展基金

摘　　要：本文在家兔双侧蓝斑下核内注入6-羟基多巴胺(6-OHDA)20~d后,用甲醛诱发荧光组织化学法显示视前区儿茶酚胺(CA)神经末梢明显减少,其中以内侧区较明显;与此同时,受体放射自显影结果表明,视前区与~3H-埃托啡特异结合的阿片受体密度也明显减少,亦以视前内侧区较显著。上述结果提示,视前区(尤其内侧区)CA 神经末梢上分布有阿片受体。The formaldehyde histofluorescence method and receptor autoradiographywere respectively used to investigate the distribution and densities of the catechol-amine(CA)terminals and[~3H]-etorphine binding sites,after 20 days of injectionof 6-hydroxydopamine(6-OHDA)into N.subcoeruleus of the rabbit.The results showed that both CA terminals and [~3H]-etophine binding sites in thepreoptic area,especially in the medial preoptic area,were reduced in 6-OHDApretreated animals,thus suggesting the possible location of opioid receptors on theCA terminals.

关 键 词：兔 视前区 阿片 受体 多巴胺 

分 类 号：Q959.836[生物学—动物学]