Kindlin与整合素的活化  

Kindlin and Integrin Activation

作　　者：黄建松[1] 陶岚岚[1] 周玉兰[1] 奚晓东[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院,上海血液学研究所,医学基因组学国家重点实验室,上海200025

出　　处：《中国细胞生物学学报》2010年第4期649-655,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.30710103905);上海市科委(No.0941070-6800)资助项目~~

摘　　要：整合素通过双向信号介导细胞与细胞外基质、细胞与细胞的粘附以及细胞的迁移。先前的研究确认talin头部N端的FERM结构域与整合素β亚基胞内段近膜端的NPxY基序相互作用是活化整合素最后的共同通路。近年来研究者发现kindlin C端的FERM结构域能够与整合素β亚基胞内段远膜端的NxxY基序相互作用而协同talin活化整合素,因此kindlin已成为整合素活化机制研究的热点。kindlin家族有三个成员:kindlin-1、kindlin-2、kindlin-3,它们有着很高的氨基酸序列同源性和相同的结构。本文总结了kindlin的分布、结构和功能及kindlin在整合素活化中的机制研究的最新进展。Bidirectional integrin signaling mediates cell-extracellular matrix, cell-cell adhesion and cell migration. Mechanisms have been established whereby the FERM domain in the N-terminal region of talin binding to the membrane-proximal NPxY motif in the integrin β cytoplasmic domian constitutes a final common step of signaling leading to integrin activation. Recent studies have shown that the interactions between FERM domain in the C-terminal region of kindlins and the membrane-distal NxxY motif in the integrin β cytoplasmic domain synergize with talin to activate integrin. There are three mammalian kindlins including kindlin-1, kindlin-2, kindlin-3 and the three human kindlins exhibit a high homology in amino acid sequence and an identical domain architecture as well. This review summarizes the distribution, domain structure and molecular activities of kindlins and provides a current overview of the roles of kindlins in integrin activation.

关 键 词：kindlin 整合素 TALIN 双向信号 活化 

分 类 号：Q26[生物学—细胞生物学]