电阻抗法进行细菌药物敏感试验研究  

Electrical Impedance Method for Bacteriological Study of Drug Sensitivity Test

作　　者：王洪志[1,2] 庞小峰[1] 王爱华[2] 

机构地区：[1]电子科技大学生命科学技术学院生物电磁学与生物电子技术重点实验室,成都610054 [2]西南民族大学生命科学与技术学院生理实验室,成都610041

出　　处：《生物医学工程学杂志》2010年第4期916-919,共4页Journal of Biomedical Engineering

摘　　要：用自制的微生物电阻抗传感器和实验装置,测量已接种细菌的培养基电阻抗,并将细菌在培养期内取得的所有值描记成阻抗曲线图。因正常细菌培养基所产生的阻抗曲线图与在细菌培养基中滴加了抗菌药物所形成的阻抗曲线图形态有明显差别,这种阻抗曲线图的形态差别可用来判断细菌的药物敏感性。该研究对实现临床快速药物敏感试验,药敏检测自动化、智能化有一定的实际意义。In this study,our self-made micro-electrical impedance sensors and experimental apparatus were used to measure the impedance of bacteria-inoculated medium.Then the bacteria in the culture of all values obtained during the period were recorded into the trace impedance curve.Seeing the obvious difference in morphological change,we utilized the differed impedance curves in an attempt to estimate the morphological difference between the drug sensitivity of bacteria.The studies of clinical medicine for achieving rapid drug sensitivity test,automation and intelligentization of drug sensitivity are of practical significance.

关 键 词：电阻抗 细菌 曲线 药物敏感 

分 类 号：R319[医药卫生—基础医学]