碳纳米管/聚氨酯复合材料的制备及生物相容性评价  

Preparation and biocompatibility evaluation of polyurethane filled with carbon nanotubes

作　　者：孟洁[1,2] 郭小天[1,2] 孔桦[1,2] 杨曼[1,2] 许振[1,2] 许海燕[1,2] 

机构地区：[1]中国医学科学院基础医学研究所 [2]北京协和医学院基础学院生物医学工程系,北京100005

出　　处：《基础医学与临床》2010年第9期897-901,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(30270394;90606018)

摘　　要：目的制备和评价碳纳米管/聚氨酯复合材料的生物相容性。方法通过溶胶-凝胶方法制备碳纳米管/聚氨酯复合材料,对其力学性能进行测试;根据ISO10993指南,选取溶血实验、动态凝血实验、血小板黏附实验、血小板活化实验、细胞毒性实验和材料局部植入方法对复合材料的生物相容性进行评价。结果复合材料无明显细胞毒性,并表现出比聚氨酯材料更好的抗溶血性能、动态凝血性能、抑制血小板黏附性能以及组织相容性。结论碳纳米管/聚氨酯复合材料具有优良的生物相容性,可以作为制备组织工程细胞生长支架、人工血管、药物载体的基础材料。Objective To prepare and evaluate the biocompatibility of carbon nanotubes-polyurethane composite.Methods Multiwalled carbon nanotubes were introduced into a polyurethane elastomer through process of sol-gel.The biocompatibilities including cytotoxcicity,tissue compatibility,hemolysis,dynamic coagulation time,and platelets activation was evaluated according to the guideline of ISO10993.The tensile strength and elongation rate of the composite were also tested.Results The composite showed the excellent mechanical property of polyurethane;meanwhile,there was nocytotoxicity observed with fibroblasts,inflammation was inhibited,and platelets activation was significantly decreased.Conclusion A new composite of carbon nanotube-polyurethane were obtained and its biocompatibility was improved notably.

关 键 词：生物相容性 抗凝血 炎性反应 复合材料 聚氨酯 

分 类 号：R318.08[医药卫生—生物医学工程]