左旋四氢巴马汀加强电针对兔大脑皮层牙髓诱发电位的抑制作用  

POTENTIATING EFFECT OF L-TETRAHYDROPALMATINE ON THE SUPPRESSION OF CORTICAL TOOTH-PULP EVOKED POTENTIALS BY ELECTROACUNCTURE IN RABBITS

作　　者：吴钢[1] 姜建伟[1] 吴根诚[1] 曹小定[1] 

机构地区：[1]上海医科大学神经生物学教研室

出　　处：《生理学报》1990年第4期385-389,共5页Acta Physiologica Sinica

摘　　要：家兔6只,用氨基甲酸乙酯和氯醛糖麻醉,电刺激牙髓,在对侧大脑皮层体感Ⅰ区引导其诱发电位,观察诱发电位各成分与痛的关系。结果观察到,在P1、N1、P2和 N2 4个波中,P1和 P2波相对稳定。其中,P2波(波峰潜伏期:66.1±1.9ms)具有较高的阈值,且不受无镇痛作用的中枢抑制剂安定的影响,而受小剂量镇痛剂度冷丁的抑制,提示 P2波与痛有关。以 P2波的波幅为指标,进一步在12只家兔上观察了 L-THP 和电针及两者合用对诱发电位的影响。结果显示,L-THP 和电针对诱发电位均有抑制作用,且两者在作用强度和时间上存在明显的协同,提示 L-THP 具有加强电针对兔大脑皮层牙髓诱发电位中痛相关成分的抑制作用。Cortical potentials evoked by stimulation of the contralateral tooth-pulpwere recorded epidurally from the SI cortex of rabbits anesthetized with urethaneand chloralose.It was found that nociceptive components of the evoked poten-tial consisted of P1 and P2 wavelets with a relative stable peak latency of22.5±1.2 ms and 66.1±1.9 ms respectively.Higher intensity of tooth pulpstimulation was required for appearance of P2 than P1.Diazepam,a non-anal-gesic sedative,reduced P1 but not P2 amplitude.On the contrary,dolantin,an analgesic,suppressed P2 but showed no significant influence on P1.Theresults suggest that P2,but not P1 might be related to pain.The effects of 1-tetrahydropalmatine(1-THP)and electroacupuncture onP2 were observed on 12 animals.The results showed that both iv l-THP8mg/kg and electroacupuncture brought forth a decrease in P2 amplitude by40.3±14% and 59.3±10% respectively,while electroacupuncture combined with1-THP produce a further decrease in P2 amplitude by 92.8±7%.Further-more,the inhibitory periods of P2 amplitude were significantly prolonged afterelectroacupuncture combined with 1-THP.The results indicated that 1-THPenhanced the suppresion of P2 by electroacupuncture.

关 键 词：LTHP 电针 止痛 诱发电位 

分 类 号：R245.967[医药卫生—针灸推拿学]