左旋溴化N-丁基-4-吡啶甲酸薄荷醇酯离子液体合成方法的研究  

Research on the method for synthesis of(-)-N-butyl-menthyl-4-pyridinecarboxylate brominated ionic liquids

作　　者：向自伟[1] 范正军 徐良[2,3] 吴建一[1,2,3] 陈敏[2,3] 吴志超[2,3] 

机构地区：[1]江苏工业学院化学化工学院,江苏常州213164 [2]嘉兴学院生物与化工学院,浙江嘉兴314001 [3]嘉兴市化学清洁工艺重点实验室,浙江嘉兴314001

出　　处：《化学试剂》2010年第9期853-855,共3页Chemical Reagents

基　　金：浙江省自然基金资助项目(Y406470)

摘　　要：以异烟酸、(-)-薄荷醇、溴代正丁烷为原料采用两种不同路线合成了标题化合物,并通过IR、1HNMR、13CNMR等手段进行表征。研究发现,酯化后再季铵化获得手性离子液体的方法优于先季铵化后酯化,该方法合成标题化合物总收率75.2%。（-）-N-Butyl-menthyl-4-pyridinecarboxylate brominated ionic liquids were synthesized from isonicotinic acid,（-）-menthol and n-bromobutane used as raw materials through two kinds of different synthetic routes,and were characterized by IR,1HNMR,and ^13CNMR.The research showed that the route by which chiral ionic liquids were obtained via quaternization after esterification was much better than the route by which quaternization was realized before esterification and the total yield of（-）-N-butyl-menthyl-4-pyridinecarboxylate brominated ionic liquids was 75.2% obtained via this route.

关 键 词：手性离子液体 异烟酸 (-)-薄荷醇 

分 类 号：O626.3[理学—有机化学]