微波辅助下离子液体中6-氟嘌呤类物质的合成  

Green synthesis of 6-fluoropurine under microwave irradiation

作　　者：徐绍红[1] 姚鹏[1] 

机构地区：[1]新乡学院化学与化工学院,河南新乡453000

出　　处：《化学试剂》2010年第9期862-864,共3页Chemical Reagents

摘　　要：以离子液体[Bmim]BF4为溶剂,以6-氯嘌呤类物质和氟化钾为原料合成了6种6-氟嘌呤类物质,微波可以将反应时间从几十个小时缩短至10min,收率高,后处理简便。探讨了反应条件对反应的影响。产物结构经1HNMR和13CNMR确认。The microwave-assisted facile synthesis of 6-fluoropurine derivatives with KF catalyzed by triethylamine in the [Bmim]BF4 ionic liquid solvent was described.The microwave irradiation can shorten the reaction time from tens of hours to ten minutes.The products were obtained in high yields with easy work-up.The structure of products was confirmed by ^1HNMR and ^13CNMR.

关 键 词：6-氟嘌呤 6-氯嘌呤 微波 核苷 

分 类 号：O626[理学—有机化学]