二氧化碳气腹作用时间对妊娠中期大鼠β-绒毛膜促性腺激素的影响  

Effect of carbon dioxide pneumoperitoneum on β-human chorionic gonadotropin in rats with second trimester pregnancy

作　　者：邹琳[1] 吴科锋[2] 廖静[1] 张颖[1] 李英勇[1] 

机构地区：[1]广东医学院附属医院妇产科,广东湛江524001 [2]广东医学院天然药物研究与开发重点实验室,广东湛江524023

出　　处：《广东医学院学报》2010年第4期357-358,361,共3页Journal of Guangdong Medical College

基　　金：广东省科技计划项目(No.2008B030301019)

摘　　要：目的探讨二氧化碳(CO_2)气腹作用时间对妊娠中期大鼠血浆、胎盘和羊水中β-绒毛膜促性腺激素(β-HCG)水平的影响。方法 18只妊娠中期(妊娠10～15d)SD大鼠随机分为3组,每组6只。组1不接受CO_2气腹处理,组2、3分别接受15mmHg CO_2气腹作用1、2h。用ELISA检测各组大鼠血浆、胎盘和羊水中β-HCG含量。结果组3大鼠血浆和胎盘中β-HCG含量高于组1大鼠(P<0.05),组1、2血浆和胎盘组织中β-HCG含量差异无统计学意义(P>0.05)。各组羊水中β-HCG差异无统计学意义(P>0.05)。结论在相同气腹压力下,妊娠中期大鼠血浆和胎盘中β-HCG含量随气腹作用时间延长而增加,而羊水中β-HCG含量不受影响。Objective To investigate the effect of CO2 pneumoperitoneum on β -human chorionic gonadotropin （ 13 -HCG） in plasma, placcnta and amniotic fluid in pregnant rats with mid trimester. Methods Eighteen pregnant rats with mid trimester were rand-omly divided into 3 groups. Group 1 was not treated with CO2 pneumoperitoneum, while Group 2 and 3 underwent CO2 pneumope-ritoneum （15 mmHg） for 1 h and 2 h, respectively. Plasma, placenta and amniofic fluid content of β -HCG was detected by ELISA. Results Plasma and placenta level of β -HCG in Group 3 was superior to that in Group 1 （P 〈0.05）, but there was no statistical difference in plasma and placenta level of β -HCG between Group 1 and Group 2 （P〉0.05）, as well as in amniotic fluid content of β-HCG among 3 groups （P〉0.05）. Conclusion Under the same pressure of CO2 pneumopcritoneum, plasma and placenta level of β -HCG increases with the duration ofpneumoperitoneum, but amniotic fluid content of β-HCG is stable.

关 键 词：二氧化碳气腹 妊娠中期 Β-绒毛膜促性腺激素 

分 类 号：R714[医药卫生—妇产科学]