质子泵抑制剂的合成研究  

Research on Synthesis of Proton Pump Inhibitors

作　　者：徐宝财[1] 张桂菊[1] 

机构地区：[1]北京工商大学化学与环境工程学院北京市植物资源研究开发重点实验室,北京100048

出　　处：《精细化工》2010年第9期833-839,共7页Fine Chemicals

基　　金：北京市自然科学基金项目(2082008);北京市属高校人才强教计划资助项目(PHR200906109)~~

摘　　要：胃酸被认为是消化性溃疡的最主要致病因素之一,无论手术治疗还是药物治疗,减少胃酸分泌都是促进溃疡愈合的最常用手段。质子泵抑制剂是一类新型的抑制胃酸分泌的药物。该文叙述了质子泵抑制剂及关键中间体2-巯基苯并咪唑化合物、2-巯基咪唑并[4,5-b]吡啶化合物、2-氯甲基吡啶化合物的合成研究概况,探讨了质子泵抑制剂的较佳合成方案和结构设计思路。Clinically duodenal and peptic ulceration are the most common diseases.The control of the gastric pH with antisecretory drugs has been proved to be an effective method in the treatment of duodenal and peptic ulcers.Proton pump inhibitors have been proved to be the most effective drugs in curing ulcers.The research advances of various synthetic methods of proton pump inhibitors were reviewed.The research advance for the synthesis of key intermediates 2-mercapto-benzimidazoles,2-mercapto-imidazopyridines and 2-chloromethyl pyridine compounds were summarized.The optimum synthetic scheme was discussed.

关 键 词：质子泵抑制剂 苯并咪唑 咪唑并[4 5-b]吡啶 

分 类 号：O621.3[理学—有机化学]