氢溴酸槟榔碱安全性评价  

The Security Evaluation on Arecoline Hydrobromide

作　　者：周绪正[1] 张继瑜[1] 李金善[1] 李剑勇[1] 魏小娟[1] 牛建荣[1] 李冰[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所/中国农业科学院新兽药工程重点开放实验室,兰州730050

出　　处：《湖北农业科学》2010年第9期2268-2271,共4页Hubei Agricultural Sciences

基　　金：国家科技支撑计划项目(2008BADB4B05);科技部科研院所技术开发研究专项(NCSTE-2006-JKZX-293);甘肃省科技重大专项(2009GS02443)

摘　　要：为了正确指导临床科学合理使用氢溴酸槟榔碱,对该药的安全性进行客观评价。依据近年来对该药毒理、药理及药效的试验结果,结合文献资料,从急性毒性试验结果,对靶动物安全用药范围、耐受情况及毒副反应和"三致"作用(致癌、致畸、致突变)及生殖毒性3个方面进行综合评述;氢溴酸槟榔碱长期、大量给药具有一定的"三致"毒性及生殖毒性,作为驱虫药物在临床实践中由于给药次数和剂量更少,虽有呕吐、腹泻等副作用,但未发现有"三致"毒性及生殖毒性,且按临床推荐剂量(1～5mg/kg)对鸡、鸭、犬等畜禽绦虫驱除效果较好。The aim was to make an objective evaluation on security of arecoline hydrobromide based on the research results and literatures in recent years and to provide scientific bases for clinical usage.The security of arecoline hydrobromide was evaluated based on acute toxicity tests,the ranges of safe medication,tolerability and toxicity as well as ＂three-induced＂ effects（carcinogensis,mutagenesis and teratogenesis） and reproductive toxicity according to the combinations of experimental results,literatures and clinical effects.Arecoline hydrobromide had ＂three-induced＂ effects and reproductive toxicity when it was used with long-term and a large amount.When it was used as antitapeworm drug in clinical application,although it could cause side-effects of vomiting and diarrhea,there were no ＂three-induced＂ effects and reproductive toxicity because the times and dosages of administration were very low.There were good effects on livestock and poultry tapeworm at the clinical recommended dose（1～5mg/kg）.

关 键 词：氢溴酸槟榔碱 急性毒性 “三致”作用 生殖毒性 

分 类 号：S859.83[农业科学—临床兽医学]