人巨细胞病毒感染与急性冠脉综合征发生的关系  

Relationship between human cytomegalovirus and acute coronary syndrome

作　　者：韩卫红[1] 李国良[1] 王强 王燕[1] 王淑霞[2] 金玉怀[3] 何新霞[1] 

机构地区：[1]河北医科大学附属哈励逊国际和平医院,河北衡水053000 [2]衡水市第二人民医院 [3]河北医科大学病原生物学教研室

出　　处：《山东医药》2010年第33期13-15,共3页Shandong Medical Journal

基　　金：衡水市科委基金资助项目(08003A)

摘　　要：目的从流行病学角度探讨人类巨细胞病毒(HCMV)感染、高敏C反应蛋白(hs-CRP)及溶血磷脂酸(LPA)在急性冠脉综合征(ACS)发生过程中的作用。方法随机选取43例急性冠脉综合征(ACS)患者、20例稳定型心绞痛(SAP)患者及23例正常对照者,采用金标免疫层析法测定HCMV-IgG、HCMV-IgM抗体,胶乳增强免疫比浊散射法检测hs-CRP、比色法测定LPA浓度。结果 ACS患者HCMV-IgG阳性率、HCMV-IgM阳性率、hs-CRP、LPA均显著高于SAP及正常对照者(P<0.05);ACS患者中HCMV-IgM(+)患者hs-CRP、LPA均高于HCMV-IgM(-)者(P<0.05);ACS患者hs-CRP水平与LPA呈正相关(P<0.05)。结论急性HCMV感染或HCMV潜伏感染的活化与ACS的发生有关,其机制可能是HCMV通过激发和加重冠状动脉炎症反应而导致ACS的发生。Objective To observe the effects of HCMV infection,hs-CRP and LPA on patients with acute coronary syndrome（ACS） from the perspective of epidemiology.Methods 43 cases of ACS patients,20 SA patients and 23 control individuals were selected at random.The gold standard immunochromatography method was used to determine HCMV-IgG,HCMV-IgM antibodies,latex enhanced immunoturbidimetric scattering method to examine the concentration of hs-CRP,and colorimetry to determine the concentration of LPA.Results The positive rates of HCMV-IgG and HCMV-IgM in ACS were significantly higher than those of SA and the control individuals,so did the concentrations of hs-CRP and LPA（all P〈0.05）.The concentrations of hs-CRP and LPA in HCMV IgM（＋） patients with ACS were higher than those in HCMV IgM（-） patients（all P〈0.05）.The levels of hs-CRP in ACS positively correlated with the LPA.Conclusions Acute HCMV infection or activation of HCMV latent infection are related to the occurrence of ACS.HCMV infection results in the coronary artery inflammation which causes the occurrence of ACS.

关 键 词：急性冠脉综合征 巨细胞病毒感染 C反应蛋白质 溶血磷脂素类 

分 类 号：R541.4[医药卫生—心血管疾病]