IL-10启动子-592基因多态性与肠易激综合征的关系  

IL-10 GENE PROMOTER-592 POLYMORPHISM AND IRRITABLE BOWEL SYNDROME

作　　者：姜英杰[1] 聂玉强[1] 赖晓波[1] 

机构地区：[1]广州市第一人民医院,广东广州510180

出　　处：《现代医院》2010年第9期8-10,共3页Modern Hospitals

基　　金：广州市医药卫生科技项目(编号:2007-YB-008)

摘　　要：目的探讨IL-10启动子-592位点基因多态性与肠易激综合征(IBS)的关系。方法采用聚合酶链式反应结合限制性内切酶技术(PCR-RFLP),对312例IBS患者及325例正常对照者的IL-10启动子-592位点进行基因型分析。结果 IL-10启动子-592位点的A等位基因的发生率在IBS组及正常对照组分别为72.8%及68.9%,两组无统计学差异;IL-10启动子-592位点A/A及A/C基因型在IBS组及正常对照组的发生率有统计学差异(p<0.05),A/A基因型在两组的发生率分别为56.1%及46.2%,A/C型分别为33.3%及45.5%。结论 IL-10启动子-592位点A/A基因型可能更易患IBS。Objective To investigate the relationship of gene polymorphism of IL-10 gene promoter-592 position with IBS.Methods 312 IBS patients and 325 controls were enrolled to this study.Their IL-10-592 genotyping was detected by PCR-restriction enzyme analysis.Results The incidences of IL-10-592 A allele frequency in IBS and control group were 72.8% and 68.9%,respectively（p〈0.05）.Differences were significant of A/A and A/C genotypes between IBS and control （p〈0.05）.Conclusion The presence of-592 A/A genotype may be related to development of IBS.

关 键 词：肠易激综合征 IL-10 基因多态性 

分 类 号：R512.62[医药卫生—内科学]