高血压合并代谢综合征游离脂肪酸水平与颈动脉内中膜增厚的关系  

Relationship between Intima-media Thickness and Free Fatty Acids in Hypertensive Patients with Metabolic Syndrome

作　　者：陈风[1] 高长征[1] 

机构地区：[1]江苏省无锡市第四人民医院心脏内科,214062

出　　处：《实用心脑肺血管病杂志》2010年第10期1414-1415,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨高血压合并代谢综合征(MS)患者游离脂肪酸(FFA)水平与颈动脉内中膜厚度(IMT)的关系。方法选择高血压合并代谢综合征组69例(MS组);单纯高血压组57例(非MS组)。检测所有患者的FFA、体质指数(BMI)、颈动脉IMT及IMT增厚发生率情况。选取健康体检者50例作为对照组(NC组)。结果 MS组的BMI、三酰甘油(TG)、空腹血糖(FPG)均高于非MS组和NC组(P均<0.05)。MS组血清FFA高于非MS组及NC组〔(562.11±55.12)μmol/L、(402.65±49.53)μmol/L和(356.23±45.93)μmol/L,P均<0.05〕。3组颈动脉IMT依次为(1.10±0.13)mm、(0.82±0.12)mm、(0.70±0.11)mm;颈动脉IMT增厚发生率依次为29.3%、21.8%、5%。结论高血压伴MS患者血中FFA水平升高与颈动脉IMT增厚相关。Objective To investigate the relationship between intima-media thickness（IMT） and free fatty acids（FFA） in hypertensive patients with metabolic syndrome（MS）.Methods IMT and FFA were detected in 69 hypertensive patients with metabolic syndrome（MS group）,57 hypertensive patients without metabolic syndrome（Non-MS group）,and 50 healthy controls（NC group）.Results The body mass index,serum levels of triglyceride,fasting blood glucose and FFA in MS group were significantly higher than those in Non-MS group and NC group.IMT in MS group,Non-MS group and NC group were：along a decreasing gradient（1.10±0.13）mm,（0.82±0.12）mm and（0.70±0.11）mm.In addition,the incidence of thickening was 29.3%,21.8% and 5%,respectively.Conclusion Serum level of FFA is associated with IMT in hypertensive patients with metabolic syndrome.

关 键 词：高血压 代谢综合征 游离脂肪酸 动脉粥样硬化 

分 类 号：R544.1[医药卫生—心血管疾病]