脑创伤后炎症反应与循环内皮祖细胞的关系  

The relationship between endothelial progenitor cells and inflammatory in sub-acute of traumatic brain injury in patients

作　　者：高剑峰[1] 王亮[1] 郭新宾[1] 张建宁[1] 崔维韻[1] 

机构地区：[1]天津医科大学总医院神经外科神经病学研究所,天津300052

出　　处：《天津医科大学学报》2010年第3期381-384,共4页Journal of Tianjin Medical University

基　　金：国家自然科学基金资助项目(30772229)

摘　　要：目的:探讨脑创伤后炎症反应与患者外周血中内皮祖细胞(EPC)动态变化的关系。方法:对71例脑创伤患者,根据其体温、血中白细胞数量等指标分为炎症组和非炎症组,采用流式细胞仪测定不同时间点的外周血EPC,并结合患者的其他临床特征进行比较分析。结果:所有患者创伤后24 h内外周血中的白细胞均显著升高,而EPC明显低于正常人(P<0.01),伤后4 d开始升高,7 d达到峰值,此后逐渐下降;伤后第4、7、14天炎症组患者白细胞数均显著高于非炎症组,但两组间血中EPC数量在第4、7天无显著差异,仅在伤后第14天,炎症组外周血中EPC明显高于非炎症组(P<0.001);非炎症组逐渐下降并回归正常。结论:炎症组相对于非炎症组脑创伤患者,炎症期外周血中EPC明显升高,可能为抗炎因子动员所至,为机体自身保护的启动。Objective： To investigate the dynamic relationship of endothelial progenitor cells（EPCs） and inflamematory in sub-acute phase of traumatic brain injury（TBI） in patients. Methods： 71 patients in subacute phase of traumatic brain injury were divided into inflammary and non-inflammary groups according to the temperature and white blood cells（WBC）, the number of EPCs were examined by using flow cytometry, and the difference between inflammatory and non-inflammatory groups was analyzed. Results： The number of circulating EPCs of patients were significantly reduced within 24 hour after brain injury, elevated from 4 days later and got peak on 7 day, then reduced later. The mumber of EPCs in inflammatory patients were significantly higher than that in non-inflammatory patients in 14th day. The WBC in all patients were stress elevated, there were not difference between the two groups. But later, the WBC in non-inflammatory patients reduced to normal but was still high in inflammatory patients. And EPCs had correlation with WBC. Conclusion： EPCs are elevated later in inflammatory patients, the reasons maybe is that EPCs are mobilized to protect the body by anti-inflammatory factors.

关 键 词：脑创伤 内皮祖细胞 白细胞 炎症因子 

分 类 号：R651.15[医药卫生—外科学]