RS67506对肠道运动的影响  

Effects of RS67506 on intestinal motility

作　　者：李晓丽[1] 许言午[2] 吴博威[3] 

机构地区：[1]山西医科大学第一医院消化科,太原030001 [2]上海中医药大学生物化学教研室 [3]山西医科大学生理教研室

出　　处：《中国药物与临床》2010年第9期994-996,共3页Chinese Remedies & Clinics

基　　金：山西省科技攻关项目(20090311057-2)

摘　　要：目的研究5-羟色胺(5-HT)4受体激动剂RS67506对小鼠肠推进运动和对大鼠离体小肠肌条运动的影响。方法应用炭末法和张力换能器分别观察RS67506对小鼠肠推进运动和对大鼠离体小肠肌条的平均收缩幅度、收缩频率和静息张力的影响,并与Cisapride的作用相比较。结果 RS67506在小剂量时对小鼠肠推进运动无明显作用,中剂量和大剂量时作用明显,并且RS67506剂量依赖性增强肌条的收缩幅度,但对肌条收缩频率和静息张力无明显作用。结论 RS67506在剂量稍大的条件下,具有与Cisapride相当的对小鼠肠推进运动的作用。它对大鼠离体小肠肌条的收缩幅度与Cisapride相似,具有剂量依赖性增强作用,如果事先加入5-HT4受体拮抗剂RS23597-190,RS67506无明显作用,这表明RS67506对平滑肌肌条的作用是通过5-HT4受体完成的。Objective To explore the effects of RS67506, a 5-HT4 receptor agonist on intestine propulsive motility in mice and smooth muscle movement of isolated small intestine in rats. Methods Charcoal powder and tonotransducer were used independently to observe the effects of RS67506 on propulsive motility of mice intestine, mean contraction amplitude and frequency, resting tension of isolated intestinal smooth muscle in rats. The findings were compared among the two approaches and also with those produced by Cisapride. Results RS67506 had no obvious effect on intestinal propulsive movement in mice at lower dosage, but the effects were significant at moderate or higher dosages. Moreover, RS67506 induced a significant, concentration-dependent increase in mean contraction am- plitude but had no obvious effect on contraction frequency and resting tension of isolated intestinal smooth muscle. Conclusion At higher dosage, RS67506 may have effects on mice intestinal propulsive movement as did Cisapride. RS67506 also exhibited Cisapride-comparable action on contraction amplitude of isolated intestinal smooth muscule in rats in a dose-dependent manner, This action was eliminated by prior addition of 5-HT4 receptor antagonist （RS23597- 190）, suggesting that the effects of RS67506 on isolated smooth muscles may be mediated by 5-HT4 receptor.

关 键 词：胃肠活动 肌细胞 平滑肌 RS67506 

分 类 号：R285.5[医药卫生—中药学]