山区医院产超广谱β-内酰胺酶细菌耐药性分析  

Drug-resistance of Extended Spectrum β-Lactamases Producing Strains in Mountain Hospitals

作　　者：郑伦和 郑剑波 梅雄 

机构地区：[1]湖北省英山县人民医院检验科,湖北英山县438700

出　　处：《中华医院感染学杂志》2010年第17期2687-2688,共2页Chinese Journal of Nosocomiology

摘　　要：目的调查山区医院产超广谱β-内酰胺酶(ESBLs)细菌的耐药现状,为临床医师用药提供科学依据。方法细菌分离、鉴定按《全国临床检验操作规程》进行;药物敏感性试验采用K-B法。结果 244株肠杆菌科细菌检出产ESBLs菌89株,总产酶率为36.5%;药敏试验结果显示,产ESBLs菌对常用抗菌药物的耐药率明显高于非产ESBLs菌。结论产ESBLs是革兰阴性杆菌对β-内酰胺类抗菌经物耐药的重要机制,对产ESBLs菌应进行监测与控制。OBJECTIVE To investigate the drug-resistance status of extended spectrum β-lactamases（ESBLs） producing strains in mountain hospitals in order to provide references for the clinical application of drugs.METHODS The isolation and identification of strains were performed according to National Clinical Laboratory Operating Procedure.K-B method was used for antimicrobial susceptibility testing.RESULTS Among 244 Enterobacteriaceae strains,89 ESBLs producers were detected.The detection rate of ESBLs was 36.5%.The susceptibility testing showed the rate of drug-resistance of the ESBLs producers was distinctly higher than that of nonproducers.CONCLUSION ESBLs-producing are the important resistance mechanisms of Enterobacteriaceae to β-lactam antibiotics.And it is necessary to monitor and control the ESBLs producers.

关 键 词：超广谱Β-内酰胺酶 耐药性 肠杆菌科细菌 

分 类 号：R378[医药卫生—病原生物学]