手术患者常见革兰阴性杆菌耐药性现状分析  

Resistance Analysis of Gram-negative Bacilli in Surgical Patients

作　　者：蔡璇[1] 施菁玲[1] 孙端阳[1] 彭少华[1] 

机构地区：[1]武汉大学人民医院检验科,湖北武汉430060

出　　处：《中华医院感染学杂志》2010年第18期2875-2876,共2页Chinese Journal of Nosocomiology

摘　　要：目的研究医院手术患者常见革兰阴性杆菌的临床分布、变迁以及对抗菌药物的耐药性。方法自2008-2009年手术患者各类标本中共获得1555株病原菌,用K-B法对病原菌进行药敏试验,结果按CLSI 2008/2009年版标准进行判断,并按WHONET5.4软件进行统计分析。结果手术患者感染常见的革兰阴性杆菌前3位为铜绿假单胞菌、大肠埃希菌、不动杆菌属(2008年)和大肠埃希菌、铜绿假单胞菌、不动杆菌属(2009年),2009年洋葱伯克霍尔德菌的检出率明显上升;大多数革兰阴性杆菌对亚胺培南、美罗培南、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦等有较好的活性。结论手术患者感染的细菌的耐药性严重,应定期监测细菌的耐药性趋势,合理用药,降低感染率。OBJECTIVE To study the in clinical distribution,variance and resistance to antibiotics of Gram-negative（G-） bacilli.METHODS A total of 1555 stains were isolated from all types of surgical patients.The antibiotics susceptibility test was determined by Kirby-Bauer.The judgment and analysis of the results were performed according to CLSI（2008/2009）and WHONET5.4.RESULTS The common G-bacteria which caused surgical infection were Pseudomonas aeruginosa,Escherichia coli,Acinetobacter spp in 2008 and E.coli,P.aeruginosa and Acinetobacter spp in 2009.In 2009,the detection rate of Burkholderia cepacia was obviously ascending.The activity of the most of G-bacilli to imipenem,meropenem cefoperazone/sulbactam,and piperacillin/tazobactam were good.CONCLUSION The drug resistance of the bacteria which cause the surgical infection is severe,the bacterial resistance trends should be periodically monitored and the rational application of antibiotics should be made to reduce the infection rate.

关 键 词：手术患者 革兰阴性杆菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]