肝移植术后新发肺癌1例临床分析附文献复习  

De novo lung cancer after liver transplantation:report of one case and literature review

作　　者：张彤[1,2] 张亚琴[3] 傅斌生[1,2] 杨扬[1,2] 蔡常洁[1,2] 陆敏强[1,2] 单鸿[3] 陈规划[1,2] 

机构地区：[1]中山大学附属第三医院肝移植中心 [2]中山大学器官移植研究所广东省器官移植研究中心,广州510630 [3]中山大学附属第三医院放射科

出　　处：《器官移植》2010年第5期281-286,共6页Organ Transplantation

基　　金：国家重点基础研究发展计划项目(973分课题)(2009CB522404);国家自然科学基金面上项目(30972914);十一五科技攻关项目(2008ZX10002-025);广东省科技计划项目(2009A030200006);广州省科技计划项目重大专项(2007A032000001);广州市科技计划项目(200921Z1-E211)

摘　　要：目的探讨肝移植术后新发肺癌的临床特点、危险因素、预防及治疗。方法回顾性分析2003年10月至2009年12月间接受肝移植术的726例受者中的1例新发肺癌病例的临床资料。结果该院肝移植术后新发肺癌发生率0.14%(1/726)。该例为男性,肝移植时年龄为57岁,从接受肝移植手术至发生肿瘤历时26个月,从确诊新发肺癌至死亡历时10个月,死于肿瘤进展、多器官功能衰竭。结论肝移植术后新发肺癌的发生率较低;确诊时间较晚,疗效不佳;重视肝移植术后随访,早期诊断和早期治疗新发肺癌是提高疗效的关键措施。Objective To analyze the clinical characteristics,risk factors,prevention and treatments of de novo lung cancer after liver transplantation（LT）.Methods The clinical data of one patient with de novo lung cancer out of the 726 patients undergoing LT from October 2003 to December 2009 were analyzed.Results The morbidity of de novo lung cancer after LT in our institution was 0.14%（1/726）.The age of the patient（male）with LT history was 57 years old.The tumor was diagnosed 26 months after LT and survived for 10 months.The patient died of tumor progression and multiple organ failure eventually.Conclusion The incidence of de novo lung cancer after LT is low with delayed diagnosis time and bad curative effect as a whole.Carefully analyzing lesion precancerous and high risk factors,early diagnosis,early treatment are the keys to improve the survival time.

关 键 词：肝移植 新发恶性肿瘤 肺癌 

分 类 号：R657.3[医药卫生—外科学]